Probing the Gene-Environment Interaction in Metabolic Disease

探讨代谢疾病中基因与环境的相互作用

• 批准号: nhmrc : 1117078
• 负责人: Prof David James
• 金额: $ 59.07万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/probing-gene-environment-metabolic-disease/946165
• 关键词: Probing; Gene; Environment; Interaction; Metabolic

A major problem with modern medicine is it is based on the law of averages, assuming everybody responds in the same way to a drug or a diet. In view of the diversity between humans as a function of genetic, epigenetic and other factors this is not the case. In the clinic there is marked variation in the response to drugs commonly used to treat patients with type 2 diabetes. This proposal seeks to embrace this complexity to develop a precision medicine approach to future medical care.

现代医学的一个主要问题是它是基于平均法则，假设每个人对药物或饮食的反应都是一样的。鉴于人类之间的多样性是遗传、表观遗传和其他因素的函数，情况并非如此。在临床上，对通常用于治疗2型糖尿病患者的药物的反应存在显著差异。该提案旨在拥抱这种复杂性，为未来的医疗保健开发一种精准医学方法。