Integrated Multimodal System for Multiplexed Imaging of Signal Transduction

用于信号转导多重成像的集成多模态系统

• 批准号: LE210100011
• 负责人: Prof David James
• 金额: $ 60.01万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE210100011
• 关键词: Integrated; Multimodal; System; Multiplexed; Imaging

This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, biochemical and chemical probes with a focus on minimizing phototoxicity. Expected outcomes include new fundamental knowledge on molecular signal transduction and cell heterogeneity; development of novel probes and methodologies and the development of new and existing interdisciplinary research collaborations.

该项目将在澳大利亚的研究环境中引入一个独特的显微镜平台和相关技术，使研究人员能够重新定义我们对分子信号转导的理解。该仪器将能够以前所未有的速度和灵敏度对活细胞进行多维成像。特色成像模式将使不同的生物，生化和化学探针的集成，重点是最大限度地减少光毒性。预期成果包括分子信号转导和细胞异质性的新的基础知识;开发新的探针和方法，以及发展新的和现有的跨学科研究合作。