Novel regulatory mechanisms for the protein kinase Akt

蛋白激酶 Akt 的新调控机制

• 批准号: DP180103482
• 负责人: Prof David James
• 金额: $ 37.13万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180103482
• 关键词: Novel; regulatory; mechanisms; protein; kinase

This project aims to investigate unique feedback/feedforward regulatory behaviour of the protein kinase Akt by combining novel mathematical modelling with innovative lab methods for assessing Akt function in live cells. The project aspires to generate new knowledge that advances signal transduction research and provide computational and lab tools that provide an important resource for other researchers. The project will provide significant benefits such as transforming efforts to design Akt therapeutics and enabling other researchers to make new discoveries.

该项目旨在通过将新的数学模型与评估活细胞中Akt功能的创新实验室方法相结合来研究蛋白激酶Akt的独特反馈/前馈调节行为。该项目渴望产生新的知识，促进信号转导研究，并提供计算和实验室工具，为其他研究人员提供重要资源。该项目将带来巨大的好处，例如改变设计Akt疗法的努力，并使其他研究人员能够做出新的发现。