Dissecting The Role of Selective Insulin Resistance In Type 2 Diabetes

剖析选择性胰岛素抵抗在 2 型糖尿病中的作用

• 批准号: nhmrc : 1061122
• 负责人: Prof David James
• 金额: $ 65.39万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-selective-2-diabetes/454869
• 关键词: Dissecting; Role; Selective; Insulin; Resistance

Insulin resistance is a clinical condition where insulin, secreted from the pancreas in response to meals, is unable to fulfill its normal function. It is intimately linked to obesity and associated diseases - type 2 diabetes, cancer and cardiovascular disease. This proposal examines mechanisms contributing to insulin resistance and how insulin resistance leads to disease. We will identify drug targets with improved specificity and lead to novel insight into the risks of current treatments.

胰岛素抵抗是一种临床状况，胰腺分泌的胰岛素对饮食的反应，不能履行其正常功能。它与肥胖和相关疾病——2型糖尿病、癌症和心血管疾病——密切相关。本提案探讨了胰岛素抵抗的机制以及胰岛素抵抗如何导致疾病。我们将以改进的特异性识别药物靶点，并对当前治疗的风险产生新的见解。