The organisation of the chromosome into distinct epigenetic domains and its link with development and disease

将染色体组织成不同的表观遗传域及其与发育和疾病的联系

• 批准号: nhmrc : 525424
• 负责人: Prof David Tremethick
• 金额: $ 34.78万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/organisation-chromosome-distinct-development-disease/76791
• 关键词: organisation; chromosome; into; distinct; epigenetic

This investigation will show that a key cellular mechanism that determines how the chromosome is organised into stable domains is by changing the make-up of chromosomal domains through the replacement of histone proteins with specialised forms of histones called variants . This fundamental research will provide important new information on how chromosomes become unstable in cancer.

这项研究将表明，决定染色体如何组织成稳定结构域的一个关键细胞机制是通过用称为变体的特殊形式的组蛋白替换组蛋白来改变染色体结构域的组成。这项基础研究将提供关于染色体如何在癌症中变得不稳定的重要新信息。