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Mechanisms underpinning the epigenetic code and the role of histone variants

Mechanisms underpinning the epigenetic code and the role of histone variants
支持表观遗传密码的机制和组蛋白变体的作用
批准号：
nhmrc : 1009850
负责人：
Prof David Tremethick
金额：
$37.53万
依托单位：
Australian National University
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2011
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2011-01-01 至 2014-12-31
来源：
https://researchdata.edu.au/mechanisms-underpinning-epigenetic-histone-variants/109434
关键词：
Mechanismsunderpinningepigeneticcoderole

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中文摘要
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英文摘要
A fundamental unanswered question in biology is how a single fertilized mammalian cell can differentiate into a multicellular organism when every differentiated cell type inherits the same DNA. Fundamental to this development process is that different sets of genes are expressed in different cell types. This investigation will show that a key mechanism to regulate gene expression is the way our DNA is covered with specifically modified and altered forms of histone proteins.
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