Mechanisms underpinning the epigenetic code and the role of histone variants

支持表观遗传密码的机制和组蛋白变体的作用

• 批准号: nhmrc : 1009850
• 负责人: Prof David Tremethick
• 金额: $ 37.53万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-underpinning-epigenetic-histone-variants/109434
• 关键词: Mechanisms; underpinning; epigenetic; code; role

A fundamental unanswered question in biology is how a single fertilized mammalian cell can differentiate into a multicellular organism when every differentiated cell type inherits the same DNA. Fundamental to this development process is that different sets of genes are expressed in different cell types. This investigation will show that a key mechanism to regulate gene expression is the way our DNA is covered with specifically modified and altered forms of histone proteins.

生物学中一个基本的悬而未决的问题是，当每种分化的细胞类型继承相同的DNA时，单个受精的哺乳动物细胞如何分化为多细胞有机体。这一发育过程的基础是不同的基因集在不同的细胞类型中表达。这项研究将表明，调控基因表达的一个关键机制是我们的DNA被特定修饰和改变形式的组蛋白覆盖的方式。