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The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome

The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome
组蛋白变异在调节表观基因组遗传和三维组织中的特殊作用
批准号:
nhmrc : 1104340
负责人:
Prof David Tremethick
金额:
$66.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2019-12-31

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中文摘要
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英文摘要
It has been more than a decade since the human genome has been completely sequenced but how this genomic information is selectively utilized to direct gene expression that is unique to each of the 200 different cell types of the human body remains to be elucidated. We have new data to suggest that it is how our genome is packaged into a variety of different and dynamic 3-dimensional structures in a cell that determines cell type specific programs of gene expression
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Uncovering an evolutionary advanced mechanism of gene expression control
  • 批准号:
    DP230101039
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $54.32万
  • 财政年份:
    2023
  • 负责人:
    Prof David Tremethick
  • 依托单位:
Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
  • 批准号:
    nhmrc : 1142399
  • 项目类别:
    Project Grants
  • 资助金额:
    $71.24万
  • 财政年份:
    2018
  • 负责人:
    Prof David Tremethick
  • 依托单位:
Dissecting a RNA-histone variant interaction and its role in splicing
  • 批准号:
    DP170102525
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $43.59万
  • 财政年份:
    2017
  • 负责人:
    Prof David Tremethick
  • 依托单位:
A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing
  • 批准号:
    nhmrc : 1058942
  • 项目类别:
    Project Grants
  • 资助金额:
    $43.82万
  • 财政年份:
    2014
  • 负责人:
    Prof David Tremethick
  • 依托单位:
国内基金
海外基金
PfAP2-R介导的PfCRT转录调控在恶性疟原虫对喹啉类药物抗性中的作用及机制研究
Sestrin2抑制内质网应激对早产儿视网膜病变的调控作用及其机制研究
  • 批准号:
    82371070
  • 项目类别:
    面上项目
  • 资助金额:
    49.00万元
  • 批准年份:
    2023
  • 负责人:
    赵培泉
  • 依托单位: