Uncovering an evolutionary advanced mechanism of gene expression control

揭示基因表达控制的进化高级机制

• 批准号: DP230101039
• 负责人: Prof David Tremethick
• 金额: $ 54.32万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101039
• 关键词: Uncovering; evolutionary; advanced; mechanism; gene

This project aims to uncover a new mechanism that activates gene expression in mammals, which involves unexpected connections between the core components of chromosomes and essential enzymatic machines required for the expression of genes. This project will generate new knowledge on the poorly understood process of how the extensive genomic information of multicellular organisms is selectively chosen to enable the expression of only the required subset of genes. This will revolutionise our understanding of the mechanisms of gene control thereby shaping the field in the future. Significantly, this will allow new ways to manipulate gene expression that will impact biotechnology by providing new efficient ways to produce proteins or RNA.

该项目旨在揭示激活哺乳动物基因表达的新机制，其中涉及染色体核心成分与基因表达所需的基本酶机制之间的意想不到的联系。该项目将产生新的知识，了解如何选择性地选择多细胞生物体的广泛基因组信息，以仅表达所需的基因子集的过程。这将彻底改变我们对基因控制机制的理解，从而塑造未来的领域。 重要的是，这将允许新的方法来操纵基因表达，这将通过提供新的有效方法来生产蛋白质或RNA来影响生物技术。