How chromatin compaction is regulated and its link with disease
How chromatin compaction is regulated and its link with disease
批准号:
nhmrc : 1009851
负责人:
Prof David Tremethick
金额:
$32.92万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2014-12-31
中文摘要
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英文摘要
Chromosomes are constructed from very small particles called nucleosomes. How these nucleosomes interact with each other to build an entire chromosome is not known but elucidating this mechanism is critical in order to understand cancer when chromosomes become unstable. Furthermore, the strength of nucleosome-nucleosome interactions determines whether a gene is expressed or not. This study will elucidate the nature and the mechanism of how nucleosome-nucleosome interactions are regulated.
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