How chromatin compaction is regulated and its link with disease

染色质压缩如何调节及其与疾病的联系

• 批准号: nhmrc : 1009851
• 负责人: Prof David Tremethick
• 金额: $ 32.92万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chromatin-compaction-regulated-link-disease/109435
• 关键词: How; chromatin; compaction; regulated; its

Chromosomes are constructed from very small particles called nucleosomes. How these nucleosomes interact with each other to build an entire chromosome is not known but elucidating this mechanism is critical in order to understand cancer when chromosomes become unstable. Furthermore, the strength of nucleosome-nucleosome interactions determines whether a gene is expressed or not. This study will elucidate the nature and the mechanism of how nucleosome-nucleosome interactions are regulated.

染色体是由称为核小体的非常小的颗粒构成的。这些核小体如何相互作用以构建整个染色体尚不清楚，但阐明这一机制对于了解当染色体变得不稳定时的癌症至关重要。此外，核小体-核小体相互作用的强度决定了基因是否表达。本研究将阐明核小体-核小体相互作用是如何调控的性质和机制。