A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing
A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing
批准号:
nhmrc : 1058942
负责人:
Prof David Tremethick
金额:
$43.82万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
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英文摘要
It is estimated that greater than 90% of human genes undergo alternative RNA splicing, which can explain how protein diversity is achieved with a limited number of genes. However, how alternative splicing patterns are established remains poorly understood but is an important question given that 15-50% of human disease mutations are associated with changes to the splicing patterns of RNA. We have uncovered a new splicing mechanism, which involves changing the way DNA is packaged in a cell.
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国内基金
海外基金
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