A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing

组蛋白变异在前 mRNA 剪接的组织特异性调节中的新功能

• 批准号: nhmrc : 1058942
• 负责人: Prof David Tremethick
• 金额: $ 43.82万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-function-histone-mrna-splicing/454716
• 关键词: new; function; histone; variants; tissue

It is estimated that greater than 90% of human genes undergo alternative RNA splicing, which can explain how protein diversity is achieved with a limited number of genes. However, how alternative splicing patterns are established remains poorly understood but is an important question given that 15-50% of human disease mutations are associated with changes to the splicing patterns of RNA. We have uncovered a new splicing mechanism, which involves changing the way DNA is packaged in a cell.

据估计，超过90%的人类基因经历选择性RNA剪接，这可以解释如何用有限数量的基因实现蛋白质多样性。然而，选择性剪接模式是如何建立的仍然知之甚少，但鉴于15-50%的人类疾病突变与RNA剪接模式的变化有关，这是一个重要的问题。我们发现了一种新的剪接机制，它涉及改变DNA在细胞中的包装方式。