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Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease

Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
揭示新的基于表观遗传的基因表达调控机制:组蛋白变异、RNA 功能和疾病之间的新联系
批准号:
nhmrc : 1142399
负责人:
Prof David Tremethick
金额:
$71.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31

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中文摘要
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英文摘要
It is estimated that greater than 90% of human genes undergo alternative RNA splicing, which can explain how protein diversity is achieved with a limited number of genes. However, how alternative splicing patterns are established remains poorly understood but is an important question given that 15-50% of human disease mutations are associated with changes to the splicing patterns of RNA. We have uncovered a new splicing mechanism, which involves changing the way DNA is packaged in a cell.
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Uncovering an evolutionary advanced mechanism of gene expression control
  • 批准号:
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  • 项目类别:
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  • 财政年份:
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The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome
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  • 项目类别:
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A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing
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    nhmrc : 1058942
  • 项目类别:
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  • 负责人:
    Prof David Tremethick
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  • 批准号:
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  • 项目类别:
    面上项目
  • 资助金额:
    48.00万元
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    焦英甫
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