Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
批准号:
nhmrc : 1142399
负责人:
Prof David Tremethick
金额:
$71.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31
中文摘要
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英文摘要
It is estimated that greater than 90% of human genes undergo alternative RNA splicing, which can explain how protein diversity is achieved with a limited number of genes. However, how alternative splicing patterns are established remains poorly understood but is an important question given that 15-50% of human disease mutations are associated with changes to the splicing patterns of RNA. We have uncovered a new splicing mechanism, which involves changing the way DNA is packaged in a cell.
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财政年份:2016
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A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing
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批准号:nhmrc : 1058942
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财政年份:2014
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Understanding how dynamic changes in chromatin composition control genome function
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批准号:DP140101268
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项目类别:Discovery Projects
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资助金额:$31.68万
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财政年份:2014
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A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants
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批准号:nhmrc : 1058941
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资助金额:$44.86万
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财政年份:2014
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依托单位:
Mechanisms underpinning the epigenetic code and the role of histone variants
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批准号:nhmrc : 1009850
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财政年份:2011
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依托单位:
How chromatin compaction is regulated and its link with disease
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财政年份:2011
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依托单位:
The organisation of the chromosome into distinct epigenetic domains and its link with development and disease
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资助金额:$34.78万
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财政年份:2009
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依托单位:
Regulation of the histone code by histone variants
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批准号:nhmrc : 471422
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财政年份:2008
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依托单位:
Chromatin remodelling and transcriptional regulation of CD8 T cell effector gene expression
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批准号:nhmrc : 454455
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项目类别:NHMRC Project Grants
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资助金额:$35.45万
-
财政年份:2007
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负责人:Prof David Tremethick
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依托单位:
The Dynamic Control of Chromatin Structure
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批准号:DP0774014
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资助金额:$18.25万
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财政年份:2007
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负责人:Prof David Tremethick
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依托单位:
Mechanism of higher-order chromatin formation and its role in controlling gene expression
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批准号:DP0450154
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项目类别:Discovery Projects
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资助金额:$29.25万
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财政年份:2004
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负责人:Prof David Tremethick
-
依托单位:
国内基金
海外基金
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