A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants

控制细胞功能的新范例：组蛋白变体动态重塑表观基因组

• 批准号: nhmrc : 1058941
• 负责人: Prof David Tremethick
• 金额: $ 44.86万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-paradigm-control-histone-variants/454715
• 关键词: new; paradigm; control; cellular; function

Our DNA is packaged and partitioned into stable identities, chromosomes, which is critical for proper cell function and the inheritance of our genetic material from one cell generation to the next. Loss of chromosome integrity leads to cancer and therefore the cell must ensure that this does not happen. We have uncovered a new mechanism whereby different components of chromosomes can dynamically move from one location to another to ensure chromosomes remain stable when they are challenged.

我们的DNA被包装并划分为稳定的身份，染色体，这对于正常的细胞功能和遗传物质从一代细胞到下一代细胞的遗传至关重要。染色体完整性的丧失会导致癌症，因此细胞必须确保这种情况不会发生。我们发现了一种新的机制，染色体的不同成分可以动态地从一个位置移动到另一个位置，以确保染色体在受到挑战时保持稳定。