A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants
A new paradigm for the control of cellular function: the dynamic reshaping of the epigenome by histone variants
批准号:
nhmrc : 1058941
负责人:
Prof David Tremethick
金额:
$44.86万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Our DNA is packaged and partitioned into stable identities, chromosomes, which is critical for proper cell function and the inheritance of our genetic material from one cell generation to the next. Loss of chromosome integrity leads to cancer and therefore the cell must ensure that this does not happen. We have uncovered a new mechanism whereby different components of chromosomes can dynamically move from one location to another to ensure chromosomes remain stable when they are challenged.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Uncovering an evolutionary advanced mechanism of gene expression control
-
批准号:DP230101039
-
项目类别:Discovery Projects
-
资助金额:$54.32万
-
财政年份:2023
-
负责人:Prof David Tremethick
-
依托单位:
Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
-
批准号:nhmrc : 1142399
-
项目类别:Project Grants
-
资助金额:$71.24万
-
财政年份:2018
-
负责人:Prof David Tremethick
-
依托单位:
Dissecting a RNA-histone variant interaction and its role in splicing
-
批准号:DP170102525
-
项目类别:Discovery Projects
-
资助金额:$43.59万
-
财政年份:2017
-
负责人:Prof David Tremethick
-
依托单位:
The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome
-
批准号:nhmrc : 1104340
-
项目类别:Project Grants
-
资助金额:$66.24万
-
财政年份:2016
-
负责人:Prof David Tremethick
-
依托单位:
A new function for histone variants in the tissue-specific regulation of pre-mRNA splicing
-
批准号:nhmrc : 1058942
-
项目类别:Project Grants
-
资助金额:$43.82万
-
财政年份:2014
-
负责人:Prof David Tremethick
-
依托单位:
Understanding how dynamic changes in chromatin composition control genome function
-
批准号:DP140101268
-
项目类别:Discovery Projects
-
资助金额:$31.68万
-
财政年份:2014
-
负责人:Prof David Tremethick
-
依托单位:
Mechanisms underpinning the epigenetic code and the role of histone variants
-
批准号:nhmrc : 1009850
-
项目类别:Project Grants
-
资助金额:$37.53万
-
财政年份:2011
-
负责人:Prof David Tremethick
-
依托单位:
How chromatin compaction is regulated and its link with disease
-
批准号:nhmrc : 1009851
-
项目类别:Project Grants
-
资助金额:$32.92万
-
财政年份:2011
-
负责人:Prof David Tremethick
-
依托单位:
The organisation of the chromosome into distinct epigenetic domains and its link with development and disease
-
批准号:nhmrc : 525424
-
项目类别:NHMRC Project Grants
-
资助金额:$34.78万
-
财政年份:2009
-
负责人:Prof David Tremethick
-
依托单位:
Regulation of the histone code by histone variants
-
批准号:nhmrc : 471422
-
项目类别:NHMRC Project Grants
-
资助金额:$39.3万
-
财政年份:2008
-
负责人:Prof David Tremethick
-
依托单位:
Chromatin remodelling and transcriptional regulation of CD8 T cell effector gene expression
-
批准号:nhmrc : 454455
-
项目类别:NHMRC Project Grants
-
资助金额:$35.45万
-
财政年份:2007
-
负责人:Prof David Tremethick
-
依托单位:
The Dynamic Control of Chromatin Structure
-
批准号:DP0774014
-
项目类别:Discovery Projects
-
资助金额:$18.25万
-
财政年份:2007
-
负责人:Prof David Tremethick
-
依托单位:
Mechanism of higher-order chromatin formation and its role in controlling gene expression
-
批准号:DP0450154
-
项目类别:Discovery Projects
-
资助金额:$29.25万
-
财政年份:2004
-
负责人:Prof David Tremethick
-
依托单位:
国内基金
海外基金
范型(Paradigm)统一化问题
-
批准号:68783007
-
项目类别:专项基金项目
-
资助金额:3.0万元
-
批准年份:1987
-
负责人:林惠民
-
依托单位: