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The Dynamic Control of Chromatin Structure

The Dynamic Control of Chromatin Structure
染色质结构的动态控制
批准号:
DP0774014
负责人:
Prof David Tremethick
金额:
$18.25万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2007
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2007-01-01 至 2010-12-31

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中文摘要
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英文摘要
A human chromosome is a highly heterogeneous global structure because along its axis, it folds to different extents to form either highly compacted domains that repress the expression of genes or less condensed regions that enable genes to be turned on. Changes to the structure or stability of chromosomes, and the corresponding alterations to gene expression, have been linked to many diseases states like defects in human development and cancer. This study will uncover the underpinning mechanism of how our chromosomes are organised into distinct functional domains, which may offer the potential to develop new strategies to correct chromosomal abnormalities.
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Uncovering an evolutionary advanced mechanism of gene expression control
  • 批准号:
    DP230101039
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $54.32万
  • 财政年份:
    2023
  • 负责人:
    Prof David Tremethick
  • 依托单位:
Uncovering new epigenetic-based regulatory mechanisms of gene expression: novel links between histone variants, RNA function and disease
  • 批准号:
    nhmrc : 1142399
  • 项目类别:
    Project Grants
  • 资助金额:
    $71.24万
  • 财政年份:
    2018
  • 负责人:
    Prof David Tremethick
  • 依托单位:
Dissecting a RNA-histone variant interaction and its role in splicing
  • 批准号:
    DP170102525
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $43.59万
  • 财政年份:
    2017
  • 负责人:
    Prof David Tremethick
  • 依托单位:
The special role of histone variants in regulating the inheritance and 3-dimensional organisation of the epigenome
  • 批准号:
    nhmrc : 1104340
  • 项目类别:
    Project Grants
  • 资助金额:
    $66.24万
  • 财政年份:
    2016
  • 负责人:
    Prof David Tremethick
  • 依托单位:
国内基金
海外基金
Cortical control of internal state in the insular cortex-claustrum region