Understanding how dynamic changes in chromatin composition control genome function

了解染色质组成的动态变化如何控制基因组功能

• 批准号: DP140101268
• 负责人: Prof David Tremethick
• 金额: $ 31.68万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101268
• 关键词: Understanding; how; dynamic; changes; chromatin

DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and determine the architecture of several chromatin states with unique functional implications inside the cell. This will unravel the molecular instructions that define how our genomes are organised, significantly advancing our knowledge of fundamental eukaryotic genome biology and paving the way for the future development of new tools and therapies.

DNA在真核细胞中以染色质的形式紧密包装。重要的遗传过程，如转录，需要操纵染色质结构来访问DNA。该细胞建立特殊的染色质结构来调节这些过程。目前，这些特殊结构的精确分子细节是有限的。该项目将推动体外模型染色质系统的发展，并确定细胞内具有独特功能含义的几种染色质状态的结构。这将揭开定义我们基因组如何组织的分子指令，极大地促进我们对基本真核基因组生物学的了解，并为未来新工具和疗法的发展铺平道路。