Discovery of best stabilizing agents for lyophilized enzyme and antibody reagents in long-term room temperature storage conditions

发现长期室温储存条件下冻干酶和抗体试剂的最佳稳定剂

• 批准号: 519840-2017
• 负责人: Williamson, Vanessa
• 金额: $ 1.82万
• 依托单位: Seneca College of Applied Arts and Technology
• 依托单位国家: 加拿大
• 项目类别: Applied Research and Development Grants - Level 1
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=641367
• 关键词: Discovery; best; stabilizing; agents; lyophilized

Ottawa-based Evik Diagnostics manufactures lyophilized/freeze-dried reagents for a large US environmental testing company. They are now ramping up pilot manufacturing to support entry to other export markets, including Canada. Through this project, Evik will collaborate with Dr. Frank Merante and student research assistants from Seneca's School of Biological Sciences and Applied Chemistry (BSAC) to develop of a point-of-use immunoassay employing reagents with an extended shelf life at room temperature that will complement the existing Evik product pipeline. The research focus will be on investigating novel ways to create prolonged stability through the introduction of excipients to the base reagents, and will concurrently provide the opportunity to enhance enzymatic activity and associated assay performance.

总部位于渥太华的Evik Diagnostics为一家大型美国环境测试公司生产冻干/冻干试剂。他们现在正在扩大试点制造业，以支持进入包括加拿大在内的其他出口市场。通过这个项目，Evik将与Seneca生物科学与应用化学学院（BSAC）的Frank Merante博士和学生研究助理合作，开发一种使用点免疫测定法，使用在室温下延长保质期的试剂，这将补充现有的Evik产品线。研究重点将是研究通过在基础试剂中引入辅料来创造长期稳定性的新方法，并同时提供提高酶活性和相关分析性能的机会。