Organic Transformations with eta2-Arene Complexes

当配位芳烃与适当的二氢配位剂一起使用时，可以作为各种单环和多环天然产物的有价值的合成子。为了测试和发展这一假说，研究计划将解决三个主要问题：i)通过这种技术可以实现哪些用传统方法难以实现的有机转变，ii)这种转变的立体化学可以在多大程度上由过渡金属控制，以及iii)如何改变络合剂的性质以实现a)芳香族底物的更大活性b)不对称诱导，以及c)用于各种目标反应的催化循环？有机合成计划将支持弗吉尼亚大学W·迪恩·哈曼博士的研究。这项研究将发展配位芳烃过渡金属络合物的反应，形成取代的环状产物，具有缩短某些合成序列的效果。这种新的合成方法应该有利于生物化学和医学以及化学工业的研究。

Coordinated arenes can serve as valuable synthons to a variety of mono-and polycyclic natural products when used in conjunction with an appropriate dihapto-coordination agent. In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle for various target reactions? %%% With this award, the Organic Synthesis Program will support the research of Dr. W. Dean Harman at the University of Virginia. The research will develop the reactions of coordinated arene transition metal complexes to form substituted cyclic products which has the effect of shortening certain synthetic sequences. This new synthetic methodology should benefit research in biochemistry and medicine as well as in the chemical industry.