Oxo-Organometallic Chemistry

华盛顿大学的詹姆斯·迈耶教授将 开展含氧有机金属化学的基础研究， 支持无机，生物无机和有机 程序. 这将是一个三管齐下的努力， 发现和发展的反应，其中金属氧代 功能涉及到的根本性转变 有机分子 钨膦类化合物 WCl_2（PR_3）_4在氧提取中的应用 与醇、三甲基甲硅烷基醚和 羧酸盐。 涉及硫代和亚氨基的类似反应 还将研究功能。 的所述第二区域中 研究，化学的铯氧乙炔化合物将 被探索。 这些反应将包括氢氧化物， 氧氢化物迁移以及还原和去质子化。 的 第三个研究领域将审查 氧代-三（吡唑基）硼酸鎓化学，具体地 光化学芳烃活化和迁移插入的 氧代基团转化为鎓-烷基键。 这些研究将导致 在这一领域知识的普遍扩大 氧代有机金属化学，具有潜在的应用， 主要工业含氧有机化合物。 %%% 有机金属化学领域已经看到了巨大的 在商业有机化合物化学中的应用。 这笔赠款将支持扩大有机金属 有机化合物的化学 氧原子，如醇、醚和酸。 的 碳-氧键的控制操作是 这项研究的目的，这将利用高度 含金属化合物的多功能特性 钨和镍。

Professor James Mayer of the University of Washington will conduct basic research on oxo-organometallic chemistry with support from the Inorganic, Bioinorganic, and Organometallic Program. This will be a three-pronged effort towards discovering and developing reactions in which the metal-oxo functionality is involved in fundamental transformations of organic molecules. Tungsten-phosphine compounds of the type WCl2(PR3)4 will be investigated in their oxygen-abstraction reactions with alcohols, trimethylsylyl ethers, and carboxylates. Similar reactions involving sulfido and imido functionalities will also be studied. In the second area of research, the chemistry of rhenium-oxo-acetylene compounds will be explored. These reactions will include hydroxide to oxo-hydride migrations, and reductions and deprotonations. The third area of research will examine rhenium-oxo-tris(pyrazolyl)borate chemistry, specifically photochemical arene activation and migratory insertion of the oxo group into rhenium-alkyl bonds. These studies will lead to a general broadening of knowledge in the area of oxo-organometallic chemistry, with potential applications to major industrial oxo-organic compounds. %%% The field of organometallic chemistry has seen great application in the chemistry of commercial organic compounds. This grant will support an extension of organometallic chemistry into the chemistry of organic compounds containing oxygen atoms, such as alcohols, ethers, and acids. The controlled manipulation of the carbon-oxygen bonds is the objective of this research, which will exploit the highly versatile properties of compounds containing the metals tungsten and rhenium.