Upgrade of an NMR Spectrometer

9312233戈登化学研究仪器项目的这一奖项将帮助哈佛大学化学系购买500兆赫兹多核核磁共振(核磁共振)光谱仪的升级。这次升级将大大加强以下领域的研究：1)有趣和具有挑战性的分子的全合成：(A)米洛雌酚，一种具有有趣生物学特性的东方草药的结构新成分，(B)芍药苷，一种复杂的多环植物糖苷和(C)肿瘤血管生成的抑制剂，如卵黄素，2)孢子虫毒素的天然产物合成，3)C-和O-糖苷的构象研究，4)多聚醚大环内酯盐，5)信号蛋白的结构和功能研究，6)核酸和核酸结合蛋白的结构和机理研究%核磁共振(核磁共振)光谱仪用于获得关于分子结构(存在什么类型的碳和/或氢原子和/或杂原子，每种类型的原子的相对数量以及它们在分子中如何相互连接)和分子动力学(分子的不同部分运动的速度有多快)的信息。该仪器对于任何有意义的现代合成化学研究项目都是必不可少的。***

9312233 Gordon This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at Harvard University in the purchase of an upgrade for a 500 MHz, multinuclear, nuclear magnetic resonance (NMR) spectrometer. This upgrade will enhance greatly research in a number of areas including the following: 1) Total synthesis of interesting and challenging molecules such as: (a) miroestrol, a structurally novel ingredient of an oriental medicinal herb with interesting biological properties, (b) paeoniflorin, a complex polycyclic plant glucoside and (c) inhibitors of tumor angiogenesis such as ovalicin, 2) Natural product synthesis of palytoxin, 3) Conformational studies of C- and O-glycosides, 4) Polyether macrolide halichondrins, 5) Structural and functional studies of signaling proteins, 6) Structural and mechanistic studies of nucleic acids and nucleic-acid binding proteins, %%% A nuclear magnetic resonance (NMR) spectrometer is used to obtain information about molecular structure (what types of carbon and/or hydrogen atoms and/or hetero-atoms are present, what are the relative number of each type of atoms and how are they connected to one another in the molecule) and molecular dynamics (how rapidly are the various parts of the molecule moving). This instrument is essential for any meaningful, modern synthetic chemistry research program. ***