NMR Spectroscopy in the Undergraduate Chemistry Laboratories

该项目涉及购买一台核磁共振(核磁共振)光谱仪(瓦里安单位INOVA 300 Nb)和一个为分析从光谱仪获得的数据而设计的软件包。这一设备使大量本科生能够获得他们自己的个人样品的光谱。然后，学生可以在计算机上分析数据，解释光谱，并在必要时返回计算机，以完善光谱的某些特征。在有机化学实验室，有五个实验涉及用这个仪器回答结构问题。此外，交替的有机实验室部门每周都会使用光谱仪来表征合成的其他化合物。这种持续的使用有力地加强了学习过程。光谱仪也同样用于无机化学实验室，用于回答结构问题和表征合成的产品。在更高级别的实验室中，分光计正被用于展示更先进技术的实验。生物化学实验室正在使用这种仪器来研究蛋白质动力学。先进的实验室正在利用机器的变温能力来测量平衡常数。Inova 300 Nb能够在300 MHz的相当高的磁场下进行所有现代核磁共振实验，这足以满足本科生的实验需要。该项目是一个更大的项目的一部分，该项目将计算机和仪器引入课堂和实验室，以进一步发展学生在设备与计算机接口、处理和操纵信息以及交流他们的实验结果方面的技能。*

This project involves the purchase of a nuclear-magnetic-resonance (NMR) spectrometer (Varian Unity INOVA 300 NB) and a software package designed for the analysis of data obtained from the spectrometer. This equipment enables a large number of undergraduate students to obtain spectra for their own individual samples. The students can then analyze the data on the computer, interpret the spectra, and, when necessary, return to the computer to refine some feature of the spectra. In the organic chemistry laboratory, five experiments involve this instrument being used to answer structural questions. In addition, alternating organic laboratory sections are using the spectrometer on a weekly basis to characterize the other compounds that are synthesized. This continuing use strongly reinforces the learning process. The spectrometer is being similarly used in the inorganic chemistry laboratory to answer structural questions and to characterize products that are synthesized. In the higher level laboratories, the spectrometer is being employed in experiments that illustrate more advanced techniques. The biochemistry laboratory is using the instrumentation to study protein dynamics. The advanced laboratory is using the machine's variable temperature capabilities to measure equilibrium constants. INOVA 300 NB is capable of performing all the modern NMR experiments at a reasonably high field of 300 MHz, which is sufficient for undergraduate experiments. This project is part of a larger program to introduce computers and instruments into lectures and laboratories to further the development of the students' skills in device-computer interfacing, handling and manipulating information, and communicating the results of their experiments. *