NMR Spectroscopy in the Undergraduate Chemistry Laboratories

该项目涉及购买一台核磁共振（NMR）光谱仪（Varian Unity INOVA 300 NB）和一套用于分析从光谱仪获得的数据的软件包。 该设备使大量的本科生能够获得他们自己的个人样品的光谱。 然后，学生可以在计算机上分析数据，解释光谱，并在必要时返回计算机以改进光谱的某些特征。 在有机化学实验室中，有五个实验涉及使用这种仪器来回答结构问题。 此外，交替的有机实验室部门每周使用光谱仪来表征合成的其他化合物。 这种持续使用有力地加强了学习过程。 光谱仪也同样用于无机化学实验室，以回答结构问题和表征合成产物。 在更高级别的实验室中，光谱仪被用于说明更先进技术的实验。 生物化学实验室正在使用仪器研究蛋白质动力学。 先进的实验室正在使用机器的可变温度能力来测量平衡常数。INOVA 300 NB能够在300 MHz的高磁场下进行所有现代NMR实验，这对于本科实验来说已经足够了。 这个项目是一个更大的计划，将计算机和仪器引入讲座和实验室，以进一步发展学生在设备-计算机接口，处理和操纵信息，并交流他们的实验结果的技能的一部分。 *

This project involves the purchase of a nuclear-magnetic-resonance (NMR) spectrometer (Varian Unity INOVA 300 NB) and a software package designed for the analysis of data obtained from the spectrometer. This equipment enables a large number of undergraduate students to obtain spectra for their own individual samples. The students can then analyze the data on the computer, interpret the spectra, and, when necessary, return to the computer to refine some feature of the spectra. In the organic chemistry laboratory, five experiments involve this instrument being used to answer structural questions. In addition, alternating organic laboratory sections are using the spectrometer on a weekly basis to characterize the other compounds that are synthesized. This continuing use strongly reinforces the learning process. The spectrometer is being similarly used in the inorganic chemistry laboratory to answer structural questions and to characterize products that are synthesized. In the higher level laboratories, the spectrometer is being employed in experiments that illustrate more advanced techniques. The biochemistry laboratory is using the instrumentation to study protein dynamics. The advanced laboratory is using the machine's variable temperature capabilities to measure equilibrium constants. INOVA 300 NB is capable of performing all the modern NMR experiments at a reasonably high field of 300 MHz, which is sufficient for undergraduate experiments. This project is part of a larger program to introduce computers and instruments into lectures and laboratories to further the development of the students' skills in device-computer interfacing, handling and manipulating information, and communicating the results of their experiments. *