Purchase of a 400 MHz NMR Spectrometer

凭借化学研究仪器和设施（CRIF）计划的这一奖项，斯托尼布鲁克的纽约州立大学化学系将获得一台400 MHz NMR光谱仪。这一设备将使研究人员能够进行以下研究：（a）开发基于有机金属催化剂的合成工艺和开发天然产品及其同类物的合成方法（Ojima）;（B）合成具有生物活性的天然产品和设计的分子探针（帕克）; c）辅酶A类似物的合成和计算机设计的生物分子受体和传感器的开发（Drueckhammer）; d）对去整合素在哺乳动物受精中的作用和对理解酶运动的研究（Sampson）; e）全碳分子的结构和反应性（Goroff）;和f）设计的超分子结构的制备（Fowler）。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将在生物化学、生物传感器开发和材料化学等许多领域产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the State University of New York in Stony Brook will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the development of synthetic processes based on organometallic catalysts and the development of synthetic methods for natural products and their congeners (Ojima); b) synthesis of biologically active natural products and designed molecular probes (Parker); c) synthesis of analogues of Coenzyme A and development of computer-designed receptors and sensors for biological molecules (Drueckhammer); d) investigations on the role of disintegrins in mammalian fertilization and on understanding enzyme motion (Sampson); e) the structure and reactivity of all-carbon molecules (Goroff); and f) the preparation of designed supramolecular structures (Fowler). Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including biochemistry, biological sensor development, and materials chemistry.