Acquisition of an 800 MHz NMR Spectrometer for a New Jersey Statewide Facility

在Jean Baum博士的指导下，罗格斯大学获得了一笔赠款，用于购买一台800 MHz核磁共振光谱仪，这是开发新泽西州范围内800 MHz核磁共振设备的倡议的一部分。800 MHz核磁共振最初将服务于至少四所新泽西大学，包括罗格斯-新不伦瑞克(NB)、罗格斯-纽瓦克、普林斯顿大学和蒙特克莱尔州立大学(MSU)。10名教职员工，三名来自罗格斯-北卡罗来纳/RWJ，一名来自罗格斯-纽瓦克，四名来自普林斯顿，两名来自密歇根州立大学，正在参与新泽西州范围800 MHz的核磁共振设施。获得800 MHz核磁共振将使全州集团能够实施一系列目前在500和600 MHz NMR上不可行的最先进的生物核磁共振实验，并将提高他们在时间密集型核磁共振项目方面的生产率。新泽西州800兆赫核磁共振设施的建立将提高核磁共振研究和教育的质量，提高新泽西州社区的可及性。新泽西州的核磁共振社区现在可以访问目前不能在各个机构的低场仪器上进行的最先进的核磁共振研究。此外，新泽西州范围内的800 MHz核磁共振设施为本科生、研究生和博士后提供了一个机会，让他们与来自其他新泽西学校的研究人员见面，接受关于最先进的核磁共振仪器的培训，并接触到许多不同的核磁共振研究项目。让800 MHz核磁共振为许多不同的机构提供服务，为核磁共振用户提供了一个智力环境和协作框架。核磁共振实验将由大约60名参与核磁共振研究的研究生、博士后和本科生进行。该设施成员的研究活动是分子生物物理学，重点是以下领域：蛋白质结构测定；折叠和未折叠蛋白质的构象和动力学研究，以了解蛋白质折叠和错误折叠的基础；核酸结构和相互作用的研究；蛋白质-蛋白质和蛋白质-核酸相互作用的核磁共振研究；小肽的设计和构象分析；核磁共振方法的开发，用于下一代应用。我们将在新泽西州建立的800 MHz核磁共振设施将为新泽西州私立和公立大学的许多研究和教育项目提供基础设施，并提高其质量和可及性。通过将这组大学聚集在一起，我们正在建立一个合作的环境，并正在协调来自许多不同机构的核磁共振专业知识。新泽西州的800 MHz核磁共振设施为本科生、研究生和博士后提供了一个机会，让他们与来自其他新泽西学校的研究人员见面，并接触到许多不同的核磁共振研究项目。让800 MHz核磁共振为许多不同的机构提供服务，为核磁共振用户提供了一个智力环境和协作框架。

A grant has been awarded to Rutgers University under the direction of Dr. Jean Baum to purchase an 800 MHz NMR spectrometer as part of an initiative to develop a New Jersey State-Wide 800 MHz NMR Facility. The 800 MHz NMR will initially serve a minimum of four New Jersey institutions including Rutgers-New Brunswick (NB), Rutgers-Newark, Princeton University and Montclair State University (MSU). Ten faculty members, three from Rutgers-NB/RWJ, one from Rutgers-Newark, four from Princeton and two from MSU are participating in the New Jersey Wide 800 MHz NMR Facility. Access to an 800 MHz NMR will allow the State-Wide group to implement a range of state of the art biological NMR experiments that are currently not feasible on the 500 and 600 MHz NMRs and will enhance their productivity in terms of time intensive NMR projects. Establishment of the NJ State-Wide 800 MHz NMR Facility will enhance the quality and accessibility of NMR research and education to the NJ community. State of the art NMR research which cannot presently be performed on the lower field instruments that exist at the respective individual institutions will now be accessible to the New Jersey NMR community. In addition, the NJ-State wide 800 MHz NMR facility provides an opportunity for undergraduates, graduates and postdocs to meet researchers from other New Jersey schools, to be trained on state of the art NMR instrumentation and to be exposed to many different NMR research projects. Having the 800 MHz NMR serve a number of different institutions provides an intellectual environment and collaborative framework for NMR users. 'Hands on' NMR experiments will be performed by approximately 60 graduate students, postdocs as well as undergraduates involved in NMR research. The research activities of the members of the facility are in molecular biophysics with emphasis in the following areas: Protein structure determination; Conformational studies and dynamics of folded and unfolded proteins to understand the basis of protein folding and misfolding; Studies of nucleic acid structure and interactions; NMR investigations of protein-protein and protein-nucleic acid interactions; Design and conformational analysis of small peptides; NMR methods development for next generation application. The New Jersey Statewide 800 MHz NMR facility that we will establish will provide infrastructure and enhance the quality and accessibility for many research and educational programs at both private and public Universities in New Jersey. In bringing together this group of Universities, we are establishing an environment of collaboration and are coordinating expertise in NMR from many different institutions. The NJ wide 800 MHz NMR facility provides an opportunity for undergraduates, graduates and postdocs to meet researchers from other New Jersey schools and to be exposed to many different NMR research projects. Having the 800 MHz NMR serve a number of different institutions provides an intellectual environment and collaborative framework for NMR users.