An 800 MHz NMR Cryoprobe for the New Jersey Statewide NMR Facility

这笔赠款部分支持购买一个800 MHz核磁共振低温探头，该探头将安装在罗格斯大学布希科学校区。冷冻探测器技术最初将服务于至少四所新泽西大学，包括罗格斯-新不伦瑞克大学(NB)、罗格斯-纽瓦克大学、普林斯顿大学和蒙特克莱尔州立大学(MSU)。11名教职员工，三名来自罗格斯-北卡罗来纳/RWJ，两名来自罗格斯-纽瓦克，四名来自普林斯顿，两名来自密歇根州立大学，正在参与新泽西州范围内的800 MHz核磁共振设施。动手核磁共振实验将由大约60名研究生和博士后以及参与核磁共振研究的本科生进行。核磁共振设施还将通过与该设施中的教职员工和学生的研究合作，对新泽西州更多教职员工的研究和教学产生重大影响。该设备用户的研究活动是分子生物物理学，重点是以下领域：蛋白质结构测定；折叠和未折叠蛋白质的构象和动力学研究，以了解蛋白质折叠和错误折叠的基础及其相关的医疗疾病；核酸结构和相互作用的研究；蛋白质-蛋白质和蛋白质-核酸相互作用的核磁共振研究；具有重要生物医学意义的小肽的设计和信息分析；以及为下一代应用开发核磁共振方法。

This grant partially supports the acquisition of an 800 MHz NMR cryoprobe to be sited at Rutgers University, Busch science campus. The cryoprobe technology will initially serve a minimum of four New Jersey institutions including Rutgers-New Brunswick (NB), Rutgers-Newark, Princeton University and Montclair State University (MSU). Eleven faculty members, three from Rutgers-NB/RWJ, two from Rutgers-Newark, four from Princeton and two from MSU are participating in the New Jersey Wide 800 MHz NMR Facility. Hands-on NMR experiments will be performed by approximately 60 graduate students and postdocs, as well as undergraduates involved in NMR research. The NMR facility will also have significant impact on research and teaching of additional faculty members in New Jersey through the research collaborations with the faculty and students in the facility. The research activities of the users of the facility are in molecular biophysics with emphasis in the following areas: Protein structure determination; Conformational studies and dynamics of folded and unfolded proteins to understand the basis of protein folding and misfolding and their associated medical disorders; Studies of nucleic acid structure and interactions; NMR investigations of protein-protein and protein-nucleic acid interactions; Design and informational analysis of small bio-medically important peptides; and NMR methods development for next generation application.