Organic Transformations with Dihapto-Coordinated Arene Complexes

这项研究的重点是开发合成方法，利用过渡金属与芳烃的二重络合作用生成用于组装官能化多环化合物的合成子。将探索Re、W和Mo的使用，并将尝试使这种脱芳构化方法具有催化作用。通过这个续展奖项，有机和高分子化学项目支持弗吉尼亚大学化学系W·迪恩·哈曼博士的研究。哈曼教授将把工作重点放在开发芳香分子的活化和功能化方法上。芳烃或多芳烃与过渡金属的选择性结合提高了芳香族体系对亲电性的反应性，并提供了可用于后续立体选择性化学发展的活性中间体。在本科生和研究生的培训领域，更广泛的影响是强烈的，这项工作对制药行业具有重大影响。

The focus of this research is to develop synthetic methodology using the dihapto-complexation of transition metals to arenes to generate synthons for the assembly of functionalized polycyclics. The use of rhenium, tungsten and molybdenum will be explored and attempts will be made to make this dearomatization methodology catalytic. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. W. Dean Harman in the Department of Chemistry at the University of Virginia. Professor Harman will focus his work on developing methods for activation and functionalization of aromatic molecules. Selective binding of arenes or polyaromatics to transition metals enhances the reactivity of the aromatic systems towards electrophiles and affords reactive intermediates that can be used for the development of subsequent stereoselective chemistry. Broader impacts are strong in the area of training for both undergraduate and graduate students and the work has significant implications for the pharmaceutical industry.