Acquisition of a 500 MHz NMR Spectrometer to Enhance Research and Research Training Opportunities at the Department of Chemistry & Biochemistry at San Francisco State Universit

该合同支持采购高分辨率、高场500 MHz核磁共振光谱仪，该光谱仪配备脉冲场梯度、交叉极化魔角旋转（CPMAS）和可变温度附件，以及多核观测、反向宽带和CPMAS探针。该项目的具体目标是：(i)在生物分子和材料化学的结构/功能关系这两个对化学系的研究和教学任务至关重要的重点领域，扩大化学系十名教员、他们的研究生和实验室人员的研究机会，并开辟新的研究方向；（ii）加强及促进与博士学位颁授机构或私营机构的合作研究；（iii）通过接触和培训高场液态和固态核磁共振波谱的实际应用，增加本科生和研究生群体的研究活动。在与生物分子的结构和功能相关的领域，核磁共振光谱仪将允许在以下方面获得新的见解：(1)研究卟啉和金属卟啉色素纳入模型膜系统；（ii）合成结构复杂的生物碱；（iii）了解金属酶、金属肽酶抑制剂和参与DNA和RNA生物合成的酶底物类似物的结构/功能关系；（iv）以手性识别为重点的气相盐络合物取代和消除反应的研究；(v)代谢途径和线粒体复合体I和II的研究。在材料或与环境相关的材料化学领域，固体和液态核磁共振波谱将促进以下方面的研究：(1)新型沸石插层化合物，(2)环境中有机物的循环和命运，(3)砷在矿物、金属氧化物和修复材料表面的反应，以及与私营部门合作研究的硅四氮环烯复合物。这台仪器的收购将提供独特的机会，以不同的学生团体在研究和教学计划中获得现代核磁共振波谱学方面的实践培训。这台仪器的收购将启动最近聘用的少数族裔和女性教职员工的研究事业，并使他们能够追求生物分子或材料化学研究的新领域，或者在固体核磁共振波谱技术应用于环境中有机物的命运方面树立自己的榜样。作为一个为少数族裔服务的校园，旧金山州立大学很自豪能成为学生群体教育的领导者，学生群体由68%的非白人学生和61%的女性组成。因此，现代高场核磁共振应用的培训与师生合作的研究重点相结合，将为该系多样化的学生群体做好准备，迎接博士课程和劳动力的挑战。

This award supports the acquisition of a high-resolution, high-field 500 MHz NMR spectrometer that is equipped with pulsed field gradient, cross-polarization magic angle spinning (CPMAS), and variable temperature accessories, as well as a multinuclear observe, an inverse broadband, and a CPMAS probe. The specific aims of the project are to (i) expand the research opportunities of ten faculty members in the Department of Chemistry & Biochemistry, their research students, and laboratory personnel in two of the focus areas central to the research and teaching mission of the Department, namely structure/function relationships of biomolecules and materials chemistry, and open up new lines of investigation; (ii) enhance and facilitate collaborative research with Ph.D. granting institutions or the private sector; and (iii) increase the research activities of a diverse undergraduate and graduate student population through access and training in the practical applications of liquid and solid state NMR spectroscopy at high field. In the area related to structure and function of biomolecules, the NMR spectrometer will allow new insights to be obtained in the (i) study of porphyrinic and metalloporphyrinic pigments incorporated in model membrane systems; (ii) synthesis of structurally complex alkaloids; (iii) understanding of structure/function relationships of metalloenzymes, of metallopeptidase inhibitors, and of enzyme substrate analogs involved in DNA and RNA biosynthesis; (iv) study of gas-phase salt complex substitution and elimination reactions emphasizing chiral recognition; and (v) study of metabolic pathways and mitochondrial complexes I and II. In the materials or environmentally relevant materials chemistry area, solid and liquid state NMR spectroscopy will facilitate research on (i) novel zeolite intercalation compounds, (2) the cycling and fate of organic matter in the environment, (iii) reactions of arsenic on mineral, metal oxide, and remediation material surfaces, and in silicon tetraazaannulene complexes that are studied in collaboration with the private sector. The acquisition of this instrument will provide unique opportunities to a diverse student body in both the research and instructional programs to acquire hands-on training in modern aspects of NMR spectroscopy. Acquisition of this instrument will jumpstart the research careers of recently hired minority and women faculty members and empower them to pursue new lines of biomolecular or materials chemistry research, or to establish themselves as role models in the applications of solid-state NMR spectroscopy to the fate of organic matter in the environment. As a minority-serving campus, SFSU is proud to be a leader in the education of a student body that is comprised of 68% non-white ethnicity students and 61% women. Thus, the training in modern high-field NMR applications combined with the collaborative student-faculty research focus will prepare the Department's diverse student body for the challenges awaiting them in Ph.D. programs and the workforce.