MRI: Development of an photonic force microscopic system for visualization and manipulation of biological structures and Systems

0619472Menq该研究小组建议开发一种光子力显微镜(PFM)系统，用于在生理条件下和从毫米到纳米的多个尺度上对生物结构和系统进行自动3D可视化和受控操作。将集成五(5)个子系统。在处理活体时，PFM系统采用了基于光子捕获的反馈控制，可以获得更稳定和更高精度的成像性能。如果该系统如拨款中所建议的那样，成功地与用于自动3D视觉引导的共焦显微镜集成，则可以预期在关于多样性生命系统的纳米尺度结构的基础研究方面出现新的前沿。

0619472MenqThe research group proposes to develop a photonic force microscopic (PFM) system for automated 3D visualization and controlled manipulation of biological structures and systems under physiological condition and at multiple scales ranging from mm to nm. Five (5) subsystems will be integrated. While dealing living entity, the PFM system uses feedback control based on photonic trapping that can achieve more stable and high precision performance for imaging. If the system is successfully integrated with a confocal microscope for automated 3D visual guidance, as proposed in the grant, a new frontier of basic research in nanoscale structure on diversity living systems can be anticipated.