SGER: Biophotonics Techniques for Accurate Diagnosis of Pancreatic Cancer

提出了以下具体目标：具体目标1：应用部分波谱技术提高细胞学诊断PC的能力。他们将评估以前通过ERCP或EUS获得的阳性和阴性的固定细胞学样本，以制定预测规则，重要的是，在细胞学阴性但后来被诊断为胰腺癌的样本中进行测试。这项研究的完成还将显示多机构临床试验的可行性，其中细胞学标本可以可靠地交换用于PWS分析。具体目标2：展示PWS基于对新鲜细胞学标本的分析正确识别并发胰腺癌患者的潜力。从未来临床应用的角度来看，PWS可以用于固定的或新鲜的细胞学标本。因此，重要的是比较这两种细胞学制剂(即固定细胞和新鲜细胞)的PWS诊断性能，并确定哪一种提供最佳诊断性能。

0620303BackmanThe following Specific Aims are proposed:Specific Aim 1: Apply partial wave spectroscopy (PWS) to improve the ability of cytology todiagnose PC. They will assess fixed cytological samples previously obtained either by ERCP or EUS that were positive and negative to develop prediction rules and, importantly, test it in samples including a subgroup who were cytologically negative but later were diagnosed with pancreatic cancer. The completion of this study will also show the feasibility of a multi-institutional clinical trial where cytology specimens can be reliably exchanged for PWS analysis.Specific Aim 2: Demonstrate the potential of PWS to correctly identify patients withconcurrent pancreatic cancer based on the analysis of fresh cytological specimens. From theperspective of future clinical applications, PWS can be potentially used on either fixed or fresh cytological samples. Thus, it is important to compare the diagnostic performance of PWS between these two types of cytological preparations (i.e., fixed vs. fresh cells) and determine which one provides the optimal diagnostic performance.