SGER: Biophotonics for Diagnosis of Pancreatic Cancer

CBET-0733868 Backman胰腺癌(PC)是所有主要癌症中预后最差的，五年存活率低于5%。PC致命性的原因与其在晚期被诊断的倾向有关，因为潜在的可治愈的疾病阶段通常在临床上是沉默的。存活率在很大程度上取决于PC的诊断阶段。然而，胰腺癌是隐匿性的，因为症状的发展通常预示着无法切除的疾病，因此无法治愈。阻碍PC筛查的主要障碍之一是基本上任何对胰腺的询问都可能导致严重的并发症(~20%的并发症发生率)。因此，找到一种对患者进行风险分层的预筛查方法将是设计筛查策略的关键。本项目专注于开发一种生物光子学方法(一种部分波谱显微技术)来解决这一问题。

CBET-0733868 Backman Pancreatic cancer (PC) has the worst prognosis of any major cancer, with a five-year survival rate below 5%. The reasons for the lethality of PC relates to its tendency to bediagnosed at a late stage given that potentially curable stages of disease are oftenclinically silent. Survival rate dramatically depends on the stage at which PC isdiagnosed. However, pancreatic cancer is insidious in that the development of symptomsgenerally portend unresectable and hence uncurable disease. One of the major hurdlespreventing screening for PC is that essentially any interrogation of the pancreas may leadto serious complications (~20% complication rate). Thus, finding a pre-screening method inwhich patients are risk-stratified would be critical for designing screening strategies.This project focuses on development of a biophotonics approach (a partial wave spectroscopic microscopic technique), to address this problem.