BME: High-resolution Microscopy based on Resonant Nano-Arrays

CBET-0754880，Ozcan拟议的研究计划包括通过使用共振纳米结构阵列开发一种新形式的高分辨率显微镜。这种被称为基于纳米阵列的显微镜（NAM）的新型显微镜模式可以通过例如以下方式来提高低数值孔径（NA）显微镜的空间分辨率：5倍，而不会降低其大视场（FOV）。因此，NAM可以在约5 mm 2 FOV内实现约500 nm的空间分辨率，以及200 mm 2/min的快速图像采集速度。此外，所提出的NAM概念还可以扩展到光谱的中红外部分，在5-16微米的光谱波长区域内提供约2微米的分辨率，其中包含许多生物分子的独特化学特征。该提案的主要目标是将显微镜的概念与纳米光子学和等离子体融合，以实现新的成像概念。

CBET-0754880, OzcanThe proposed research plan covers the development of a new form of high resolution microscope by using an array of resonant nanostructures. This novel microscopy modality, which is termed as NanoArray based Microscopy (NAM) can improve the spatial resolution of a low numerical aperture (NA) microscope by e.g., 5 fold without degrading its large field-of-view (FOV). As a result, NAM can achieve a spatial resolution of ~500 nm over ~5 mm2 FOV, and a fast image acquisition speed of 200 mm2/min. Furthermore, the proposed NAM concept can also be extended to the mid-infrared part of the spectrum, providing a resolution of ~2 microns in the spectral wavelength region of 5-16 microns, which contains unique chemical signatures of many biomolecules. The broad goal of this proposal is to merge the concepts of microscopywith nanophotonics and plasmonics to enable new imaging concepts.