EAGER: Lab-in-a-Smartphone

建议：1447893 PI：Cunningham，BrianInstitution：伊利诺伊大学厄巴纳-香槟分校标题：EAGER：智能手机实验室意义：低成本，强大的多模式生物传感器检测能力的广泛可用性将刺激传感应用在实验室能力缺乏或当前封闭平台仅针对非常特定的商业市场的无数环境中的加速发展。基于智能手机的检测系统有望在实验室设施不可用的情况下找到应用，例如家庭、诊所、农场或偏远地区的即时分析。在拟议的工作中开发的集成方法将使移动的传感应用成为可能，包括通过传感特定的生物标志物蛋白来诊断疾病（心脏病、癌症等）、传染病的特定识别（病毒或细菌，如通过PCR进行的），食品中过敏原的感测，食品/药品制造质量控制，假药的感测，呼吸分析，和空气/水/土壤资源的环境监测智能描述：EAGER建议的目标是利用集成的半导体激光二极管和LED作为智能手机内的照明源，以及薄膜波导/光栅耦合器将光带到样品。系统只需将待测样品放置在分析开口上即可运行，而自定义软件应用程序则控制测量的所有其他方面。所得系统将能够执行UV/可见波长吸收光谱、UV/可见波长反射光谱、拉曼光谱、表面增强拉曼光谱和无标记光学生物传感器测量。该平台将使用定制的微流控盒，旨在执行样品制备，液体混合和细胞/生物分子测定的其他步骤，这些步骤可以由整个移动的应用程序开发人员生态系统开发。

Proposal: 1447893PI: Cunningham, BrianInstitution: University of Illinois at Urbana-ChampaignTitle: EAGER: Lab-in-a-SmartphoneSignificance:The wide availability of a low-cost, robust, and multimode biosensor detection capability will spur accelerated development of sensing applications in myriad settings where laboratory capabilities are lacking, or where current closed platforms are aimed at only a very specific commercial market. Smartphone-based detection systems are expected to find applications in situations where laboratory facilities are not available such as point-of-care analysis in the home, clinic, farm, or remote locations. The integrated approach to be developed in the proposed work would enable mobile sensing applications that include diagnosis of disease through sensing of specific biomarker proteins (cardiac, cancer, and others), specific identification of infectious disease (viral or bacterial, as performed by PCR), sensing of allergens in food, food/drug manufacturing quality control, sensing of counterfeit drugs, breath analysis, and environmental monitoring of air/water/soil resourcesIntellectual Description:The goal of this EAGER proposal is to utilize integrated semiconductor laser diodes and LEDs as illumination sources within the smartphone, and a thin film waveguide/grating coupler to bring light to the sample. The system will operate simply by placing the sample-under-test over the analysis opening, while a custom software application controls all other aspects of the measurement. The resulting system will be capable of performing UV/Visible wavelength absorption spectroscopy, UV/Visible wavelength reflectance spectroscopy, Raman spectroscopy, surface-enhanced Raman spectroscopy, and label-free optical biosensor measurements. The platform will use custom microfluidic cartridges designed to perform sample preparation, liquid mixing, and other steps of cell/biomolecular assays that can be developed by the entire ecosystem of mobile application developers.