Psychophysiological methods in the context of pharmacological and behavioral treatment approaches of Gilles-de-la-Tourette Syndrome

该项目的目的是利用心理生理学方法分析药物和行为治疗干预治疗吉尔斯-德-拉-图雷特综合征（GTS）的作用模式。初步评价涉及基于计算基底神经节模型和额纹状体回路神经生物学的脑电图技术对动作控制过程的分析。作为次要参数，将使用评估GTS严重程度和生活质量的量表，并将该数据与心理生理数据相结合。除了本项目研究的应用重点外，该项目还将为儿童和青少年最普遍的神经精神疾病之一的认知功能提供见解，这可能被视为多巴胺能功能亢进的疾病模型。因此，这项研究的结果将有助于理解GTS治疗的潜在过程，以及额纹状体回路在认知控制过程中的作用。

Goal of the intended project is to analyze the mode of action of pharmacological and behavioral therapeutic interventions in the treatment of Gilles-de-la-Tourette Syndrome (GTS) using psychophysiological methods. The primary evaluation relates to the analysis of action control processes using EEG techniques on the basis of computational basal ganglia models and the neurobiology of fronto-striatal circuits. As secondary parameters, inventories assessing the severeness of GTS and quality of life will be used and this data integrated with the psychophysiological data. Besides an applied focus of research pursued in this project, the project will also provide insights into cognitive functions in one of the most prevalent neuropsychiatric disorders in childhood and youth, which may be viewed as a disease-model of dopaminergic hyperfunction. Results of the study will therefore contribute to the understanding of the processes underlying treatment of GTS and to role of fronto-striatal circuits for cognitive control processes.