Clinicopathological study of the pathogesis of the advanced atherosclerotic occlusive lesions of carotid artery.

在这项研究中，发病机制的晚期动脉粥样硬化闭塞病变的颈动脉。结果总结如下，部分结果已在几篇论文中发表。1)临床病理研究，根据几乎或完全闭塞病变及急诊动脉内膜切除术的标本，提示斑块内出血是晚期动脉粥样硬化病变最重要的发病因素。这也揭示了发达的血管血管管破裂可能是这些斑块内出血的原因。2)在实验研究中，继续制备晚期动脉粥样硬化闭塞病变动物模型。总之，在过去的三年中，虽然获得了短暂的病理改变，但无法产生足够的模型。3)除颈动脉外，颅内动脉还发生了动脉壁出血和血管血管。这些发现对颅内夹层动脉瘤发病机制的意义也进行了探讨。

In this study, pathogenesis of an advanced atherosclerotic occlusive lesion of the carotid artery.Summary of the results are as follows and part of them has been presented in a couple of papers.1) Clincopathological study, based on the specimens which were obtained from nearly or completely occluded lesions and by emergency endarterectomy, suggested that intraplaque hemorrhage is the most important pathogenetic factor of the advanced atheroscleotic lesions. It is also revealed that rupture of the developted vasavasorum should be cause of these intraplaque hemorrhage.2) In experimental study, preparation of animal model with advanced atherosclerotic occlusive lesions has been continued. In conclusion, sufficient model could not be produced in the past three years, although transient pathological changes were obtained.3) In addition to the cervical carotid arteries, development of intra-arterial wall hemorrhage and vasa vasorum were revieled in the intracranial arteries. Significance of these findings to the pathogenesis of intracranial dissecting aneurysm has benn also investigated.