Host and environmental factors of gastro-intestinal cancers in Southeast Asian countries.

我们在东南亚国家（包括越南、泰国和印度尼西亚）进行了胃癌和结直肠癌的国际生态学和病例对照研究。印度尼西亚的国际生态学研究表明，六个地区的胃癌发病率非常低，特别是幽门螺杆菌的发病率很低。目前孔敬县胃癌病例对照研究表明，食用水果和蔬菜是一个预防因素。对结直肠癌的研究表明，家族病史和食用红肉是风险因素。亚甲基四氢叶酸还原酶A1298C密码子遗传多态性与饮酒和食用红肉之间存在相互作用。

We conducted international ecological and case-control studies for gastric and colorectal cancers in Southeast Asian countries, including Vietnam, Thailand and Indonesia. International ecological studies in Indonesia have suggested that very low incidence of stomach cancer in six areas, in particular, may be due to low prevalence of Helicobacter pylori. The present case-control study for stomach cancer in Khon Kaen indicated that consumption of fruit and vegetables was a preventive factor. The study for colorectal cancer revealed that family history and consumption of red meat were risk factors. There were interactions between methylene tetra-hydro folate reductase genetic polymorphisms at codon A1298C and consumption of alcohol and red meat.