Study on bioabsorbable implant materials for surgery with poly-lactic acid

本研究的目的是开发聚乳酸等生物可吸收外科材料。我们一直在研究这些新材料的合成方法、力学性能、组织反应、生物吸收序列，以及在动物实验和临床应用方面的应用。新合成材料：以聚乳酸、聚乙醇酸、-己内酯、胶原蛋白、羟基磷灰石、抗癌药物等为主要成分制备了多种新型生物材料。加工：纤维、梭织衣服、网布、无纺布衣服、别针、板、微球等。组织反应：通过植入动物体内观察新材料的组织反应。这些材料被吸收，有轻微的异物反应，未发生肿瘤，材料消失后周围组织再生正常。吸收速度可控制在3周到3年之间。用途：用于癌症治疗的含阿霉素PLA微球，用于缝合的PLA纤维，用于缝合的PGA无纺布，PLA短钉，PGA止血剂，PLA和-己内酯抗粘剂膜，用于软组织重建的PLA网，用于PLA和HA的肋骨固定针，用于胸腔重建的PLA板。这些新材料的实验和临床应用结果都很好。

The goal of this study was to develop the bioabsorbable surgical materials with polylactic acid and so on. We have been studyding the synthesis methods, the mechanical properties, the tissue reactions, the bioabsorbing sequenece, and applying of these new materials to animal experiments and clinical uses.1. New sythesized materials : Many kinds of new biomaterials were made which were composed of Polylactic acid, Polyglycolic acid, -caprolactone, Collagen, Hydroxy-apatite and anticancer drugs.2. Fabrication : Fibers, woven clothes, meshes, non woven clothes, pins, plates and microsphere were fabricated.3. Tissue reaction : Tissue reaction of these new materials were observed by means of implantation into animals. These materials were absorbed with slight foreign body reaction and no tumorigensis, and the surrounding tissur regenerated normally after the materials disappeared. The absorbing speed could be controlled from three weeks to three years.4. Applications : Adriamycin-containing PLA microsphere for cancer therapy, PLA fiber for suture, pledget and bloster for suture with non woven cloth of PGA, PLA staple, PGA hemostate, antiadhesive membrane with PLA and -caprolactone, PLA mesh for soft tissue reconstruction, rib fix pin with PLA and HA, PLA plate for thorax reconstruction. The results of experimental and clinical applications with these new developed materials were significantly good.