Novel Synthetic Surgical Adhesive Incorporated with Biomechanical Concept

本研究项目的目的是开发一种可生物降解的合成组织胶，它是基于氨基甲酸乙酯预聚物结合可水解酯基的分子。我们之前的研究表明，专门设计的聚氨酯预聚物作为手术粘合剂，即使在大出血的情况下，也能在体内表现良好。然而，主要的缺点是生物降解速度太慢。为了改善这个问题，这里启动了一个新的研究项目。修改后的分子设计是在分子中加入可水解的可生物降解的官能团。为此，新制备了一种聚酯型多元醇，并将其掺入设计的预聚物中。用大鼠进行的体内动物实验证实，新型合成胶具有更快的生物降解性，但在非常恶劣的脉动条件下仍能保持其粘连性和机械适应性。

The purpose of this research project is to develop a biodegradable, synthetic tissue adhesive glue which is based on a urethane prepolymer incorporated with hydrolyzable ester groups is a molecule.Our previous study showed that urethane prepolymers specially designed as a surgical adhesive performed very well in vivo even in cases with massive bleeding. However, the major drawback was too slow biodegradation rate. In order to improve this problem, a new research project was initiated here.Revised molecular design was to incorporate hydrolyzable biodegradable functional groups in a molecule. To this end, a polyester type polyol was newly prepared and incorporated into a designed prepolymer. In vivo animal experiments using rats verified that new version of synthetic glue exhibited a much faster biodegradability but maintained its adhesivity and mechanical adaption in very hostile, pulsatile conditions.