Studies on development of HFRS vaccine and therapeutics

1.1993年和1995年，首席调查员有川博士和日方调查人员(桥本、森松、香羽博士)一起访问了瑞典传染病控制研究所和赫尔辛基大学病毒学研究所，并进行了信息交流和讨论。2.1993年，中国调查人员(宋和洪博士)，1995年，瑞典调查人员(尼克拉森和伦德奎斯特博士)访问了北海道大学、日本国立卫生研究所和大阪大学等日本调查机构，进行了信息交流和讨论。3.1994年，日本调查人员森松博士，在瑞典传染病控制研究所停留2个月，完成关于用ELISA检测抗体的技术交流，减少了非特异性本底反应水平和单抗的材料交换。4.1994年，中国研究员周博士在北海道大学停留了6个月…对中国接种者血清进行了月龄及中和抗体反应检测。为了检测抗体，有效地应用了瑞典研究人员建立的酶联免疫吸附试验系统和日本研究人员生产的重组抗原。所获得的结果对评估中国疫苗的效果具有重要意义。5.1994年，首席调查员(Arikawa博士)访问了中国预防医学研究院(中国预防医学研究院)，讨论了这一研究项目，并进行了初步的野外调查，以采集野生啮齿动物。6.1995年，日本研究人员日本国立卫生研究院的杉山博士和阿美博士访问了中国预防医学研究院，并在北京和西安郊区进行了野外调查。他们通过组织化学观察检查了啮齿动物体内的抗原分布。通过调查，他们建立了在中国调查人员的配合下采集野生动物器官并检测器官中病毒的系统。该调查系统将为今后的协作研究做出贡献。较少

1.In 1993 and 1995, head investigator (Dr. Arikawa), and Japanese investigators (Drs. Hashimoto, Morimatsu, Kariwa) visited Swedish Institute for Infectious Disease control, and Helsinki University Institute for Virology and made information exchange and discussions along with this research project.2.In 1993, Chinese investigators (Dr. Song and Hun), in 1995, Swedish investigators (Drs. Niklasson and Lundkvist) visited institutions of Japanese investigator such as Hokkaido University, National Institute Health of Japan and Osaka University to do information exchange and discussions along with this research project.3.In 1994, Japanese investigator, Dr. Morimatsu, stayd at Swedish Institute for Infectious Disease control for 2 months to accomplish technical exchange concerning to antibody measurements by ELISA with reduced level of nonspecific background reaction and material exchange of monoclonal antibodies.4.In 1994, Chinese investigator, Dr. Zhou, stayd at Hokkaido University for 6 m … More onths and neutralizing antibody response of vaccinee sera from China was examined. To measure the antibody, ELISA system which established by Swedish investigator and recombinant antigen which produced by Japanese investigator, were effectively applied. The obtained result was important for assess efficacy of Chinese vaccine.5.In 1994, head investigator (Dr. Arikawa) visited the institute of Chinese investigator (Chinese Academy of Preventive Medicine) for discussing this research project and carried out preliminary field survey for collecting wild rodents.6.In 1995, Japanese investigators, Drs. Sugiyama and Ami of National Institute of Health Japan, visited the Chinese Academy of Preventive Medicine and carried out field survey at suburbs of Beijing and Xian to collect field rodents. They examined the antigen distribution in the rodents by histochemical observations. Through the investigation, they established the system for collecting wild animals organs under the collaboration of Chinese investigators and examine viruses in the organs. This survey system will contribute for future collaboration study. Less