Evaluation system of chemotherapy and/or radiotherapy for patients with oral squamou cell carcinoma according to the histochemical grading

在研究口腔鳞状细胞癌（SCC）患者化疗效果的组织化学检查标志物的过程中，我们注意到癌细胞中硫酸肝素糖胺聚糖（HS-GAG）的表达与蒽环类、顺铂（CDDP）、帕霉素（APP或TPP化疗）联合化疗的效果之间的关系。通过对接受一个疗程联合化疗的SCC患者的研究，HS-GAG染色弱阳性的SCC患者的应答率明显高于染色强阳性的SCC患者。这些结果提示HS-GAG是评价APP或TPP化疗患者应答率的有效指标。另一方面，我们之前的研究表明，HS-GAG染色强阳性的SCC转移发生率明显高于弱阳性的SCC转移发生率。以上结果提示，对于HS-GAG染色呈强阳性的高转移性SCC患者，APP或TPP化疗可能无效。在本研究中，我们还研究了SCC细胞中HS-GAG表达与5-氟尿嘧啶和CDDP （FC化疗）联合化疗效果之间的可能关系，以寻找治疗HS-GAG染色强烈阳性的SCC病例的有效化疗方案。因此，即使在HS-GAG染色强烈阳性的病例中，接受FC化疗的患者的缓解率也明显高于接受APP或TPP化疗的患者。综上所述，本研究揭示了HS-GAG在SCC细胞中的表达是评估可能接受APP或TPP化疗的患者应答率的有用标志物。此外，FC化疗可能对APP或TPP化疗耐药的SCC有效。少

During the course of studies to identify markers in histochemical examinations that might be useful in evaluation of the effect of cancer chemotherapy for treatment of patients with oral squamous cell carcinoma (SCC), we noticed a relationship between the expression of heparan sulfate glycosaminoglycan (HS-GAG) in the carcinoma cells and the effect of combined chemotherapy with anthracycline, cisplatin (CDDP), and peplomycin (APP or TPP chemotherapy). As a result of the study on the SCC patients who received one course of the combined chemotherapy, the response rate of the patients with SCC weakly positive for the HS-GAG staining was significantly higher than that with SCCstrongly positive for the staining. These results suggests that HS-GAG is an useful marker for evaluation of the response rate of the patients who received APP or TPP chemotherapy.On the other hand, our previous studies have indicated that the incidence of metastasis in SCC cases strongly positive for the HS-GAG stain … More ing is significantly higher than that in cases weakly positive for the staining. From the results mentioned above, it was suggested that the chemotherapy with APP or TPP might not be effective on the treatment of the highly metastatic SCC cases which were strongly positive for the HS-GAG staining.In the present study, we also examined a possible relationship between the expression of HS-GAG in SCC cells and the effect of combined chamotherapy with 5-fluorouracil and CDDP (FC chemotherapy) in order to find an effective chemotherapy for treatment of SCC cases strongly positive for the HS-GAG staining. As a result, the response rate of the patients who received the FC chemotherapy was significantly higher than that of patients who received the APP or TPP chemotherapy even in the cases strongly positive for the HS-GAG staining.In conclusion, the present study revealed that the expression of HS-GAG in SCC cells is an useful marker for evaluation of the response rate of the patients who might be received APP or TPP chemotherapy. In addition, FC chemotherapy may be effective on the treatment of SCC which may be resistant to the APP or TPP chemotherapy. Less