Identification and analysis of two novel chemokines that regulate glucose and lipid metabolism
Identification and analysis of two novel chemokines that regulate glucose and lipid metabolism
批准号:
19591077
负责人:
TAKAHASHI Yutaka
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
私たちが同定したGI1とAC1の二つの新規ケモカインについての解析を行った。GI1(CXCL14)は肝細胞においてGHによって誘導されるケモカインとして同定したが、血中濃度がインスリンによって調節されており、脂肪細胞においてインスリン依存性のグルコース取り込みを促進することが明らかになった(BBRC 364,1037,2007)。AC1(ケマリン)は新規アディポカインとして同定したが、脂肪細胞においてインスリンシグナルを促進することを見いだし、FEBS letters 582,573,2008に報告した。
英文摘要
私たちが同定したGI1とAC1の二つの新規ケモカインについての解析を行った。GI1(CXCL14)は肝細胞においてGHによって誘導されるケモカインとして同定したが、血中濃度がインスリンによって調節されており、脂肪細胞においてインスリン依存性のグルコース取り込みを促進することが明らかになった(BBRC 364,1037,2007)。AC1(ケマリン)は新規アディポカインとして同定したが、脂肪細胞においてインスリンシグナルを促進することを見いだし、FEBS letters 582,573,2008に報告した。
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Neither intravenous nor intracerebroventricular administration of obestation affects the secretion of GH, PRL, TSH and ACTH in rats.
静脉内和脑室内给予肥胖均不影响大鼠 GH、PRL、TSH 和 ACTH 的分泌。
DOI:
--
发表时间:
2007
期刊:
Regulatory Peptides 138
影响因子:
--
作者:
[Keizo, Toda, Daisuke, Yamamoto, Mariko, Fumoto, Nobuko, Ikeshita, Elizabeth, Henny, Herningtyas, Keiji, Iida, Yutaka, Takahashi, Hidesuke, Kaji, Kazuo, Chihara, Yasuhiko, Okimura, Keizo Toda, Daisuke Yamamoto]
通讯作者:
Daisuke Yamamoto
DOI:
10.1016/j.ghir.2007.12.001
发表时间:
2008-08-01
期刊:
GROWTH HORMONE & IGF RESEARCH
影响因子:
1.4
作者:
[Chihara, K., Kato, Y., Shimatsu, A.]
通讯作者:
Shimatsu, A.
Diverse splicing abnormality caused by a homozygous mutation in the thiazide-sensitive sodium-chloride cotransporter gene in a patient with Gitelman's syndrome
吉特尔曼综合征患者噻嗪类敏感的氯化钠协同转运蛋白基因纯合突变导致多种剪接异常
DOI:
--
发表时间:
2008
期刊:
Am J Kidney Dis 51(6)
影响因子:
--
作者:
[Iida, Nozu K, Takahashi Y, Okimura Y, Kaji H, Matsuo M, Chihara K]
通讯作者:
Chihara K
Efficacy and safety of individualized growth hormone treatment in adult Japanese patients with growth hormone deficiency.
日本成年生长激素缺乏症患者个体化生长激素治疗的有效性和安全性。
DOI:
--
发表时间:
2008
期刊:
Growth Hormone & IGF Research 18
影响因子:
--
作者:
[Chihara K, et al]
通讯作者:
et al
Branched-chain amino acids and argininc suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line.
在 C2C12 细胞系中,支链氨基酸和精氨酸通过 mTOR 途径抑制 MaFbx/atrogin-1 mRNA 表达。
DOI:
--
发表时间:
2008
期刊:
Biochimica et Biophysica Acta 1780
影响因子:
--
作者:
[Herningtyas E, et al]
通讯作者:
et al
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