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Neurochemical study for post-operative delirium

Neurochemical study for post-operative delirium
术后谵妄的神经化学研究
批准号:
20591839
负责人:
MURAKAWA Masahiro
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

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中文摘要
翻译
为阐明术后妄想的神经化学基础,采用脑微透析法研究了全麻疼痛刺激和镇静对大鼠大脑皮层乙酰胆碱释放的影响。广泛使用的吸入麻醉药和镇静剂对乙酰胆碱的释放有显著影响。本研究结果提示,术后妄想的发生与脑胆碱能神经元活动的改变有关。
英文摘要
To clarify the neurochemical basis for postoperative delirium, the changes of acetylcholine release in rat cerebral cortex by the painful stimulation during general anesthesia and by the sedation were studied using brain microdialysis. The acetylcholine release was significantly affected by widely-used inhalational anesthetics and sedatives. The results of this study suggest that the occurrence of post-operative delirium is related to the changes in cholinergic neuronal activities in the brain.
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会议论文
Isoflurane suppresses the increase of acetylcholine release in the rat brain with surgical stress.
异氟醚抑制手术应激大鼠大脑中乙酰胆碱释放的增加。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hakozaki T, Imaizumi T, Hosono A, Takahashi S, Murakawa M.]
通讯作者: Murakawa M.
Effects of sedative drugs on acetyl choline release from rat cerebral cortex.
镇静药物对大鼠大脑皮层乙酰胆碱释放的影响。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Nemoto C, Hakozaki T, Obara S, Isosu T, Murakawa M.]
通讯作者: Murakawa M.
Isoflurane suppresses the increase of acetylcholine release in the rat brain with surgical stress
异氟烷抑制手术应激大鼠大脑中乙酰胆碱释放的增加
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hakozaki T, et. al.]
通讯作者: et. al.
Effects of Sedative Drugs on Acetylcholine Release from the Rat Cerebral Cortex
镇静药物对大鼠大脑皮层乙酰胆碱释放的影响
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Nemoto C, Hakozaki T, Obara S, Isosu T, Murakawa M., Nemoto C]
通讯作者: Nemoto C
Developmental studies of comprehensive training system to support an improvement of practical teaching skills
  • 批准号:
    25350334
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.16万
  • 财政年份:
    2013
  • 负责人:
    MURAKAWA Masahiro
  • 依托单位:
The brain anandmide and genaral anesthesia
  • 批准号:
    24592307
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.24万
  • 财政年份:
    2012
  • 负责人:
    MURAKAWA Masahiro
  • 依托单位:
Systematization of the methods to develop" Workshop-style teacher training" and formulation of the network-system for the support of the development
  • 批准号:
    21500942
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2009
  • 负责人:
    MURAKAWA Masahiro
  • 依托单位:
Neurochemical study far psyyootropic actions of general anesthetics
  • 批准号:
    18591712
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.37万
  • 财政年份:
    2006
  • 负责人:
    MURAKAWA Masahiro
  • 依托单位:
海外基金