Identification and functional analysis of novel bioactive peptides associated with feeding regulation and lifestyle-related disease

为了寻找与喂养调节和生活方式相关疾病相关的新型生物活性肽，我们采用孤儿受体策略和新建立的方法寻找一些候选生物活性物质。我们利用ghrelin基因缺陷小鼠或neuromed in S(NMS)，证明内源性ghrelin抑制急性心肌梗死后交感神经活动，改善预后，内源性NMS可能通过激活交感神经系统调节心血管功能。

To search for novel bioactive peptides associated with feeding regulation and lifestyle-related diseases, we used the orphan receptor strategy and newly established methods to find some candidates as novel bioactive substances. By using gene deficient mice of ghrelin or neuromed in S(NMS), we demonstrated that endogenous ghrelin suppresses sympathetic nerve activity and improves the prognosis after acute myocardial infarction, and that endogenous NMS may regulate cardiovascular function by activating the sympathetic nervous system.