Clinical and Basic Researches of Hepatic Stem Cells onLiver Regeneration as Defense Mechanism.

我们通过临床和基础研究取得了一定的成果。[研究1]我们建立了非酒精性脂肪性肝炎（NASH）相关肝硬化2/3部分肝切除术（PH）后急性肝功能衰竭的大鼠模型。HT改善模型大鼠生存的机制在短期和长期研究中进行了检查。HT组的总生存期显著长于非HT组（7天生存率分别为46.7%和7.7%）。术前HT可能通过抑制宿主肝细胞的加速生长和凋亡而改善PH后NASH相关肝硬化大鼠的生存。[研究2]我们开发了计算99 mTc-半乳糖酰人血清白蛋白（GSA）肝心曲线（ABC）之间区域感兴趣像素的软件。计算受试者工作特征曲线下面积（AUC），用于评价Child-Pugh评分B级（Child B）、病理性慢性肝炎（CH）和肝硬化（LC）。我们开发了一种新的肝功能指标，ABC，顺序计数放射性。

We have achieved the results by the clinical and basic studies.【Study 1】We developed a rat model of acute liver failure after 2/3 partial hepatectomy (PH) for non-alcoholic steatohepatitis (NASH)-related cirrhosis. The mechanism by which HT improved the survival of the model rats was examined in short- and long-term investigations. Overall survival was significantly longer in the HT group than the non-HT group (7-day survival rates: 46.7% and 7.7%, respectively). Preoperative HT might improve the survival of rats with NASH-related cirrhosis after PH by preventing the host hepatocytes from accelerating their growth and falling into apoptosis. 【Study 2】We developed software to calculate the pixels of interest in the area between the hepatic and heart curves (ABC) of 99mTc-galactocyl human serum albumin (GSA) scintigraphy. The area under the receiver operating characteristic curve (AUC) was calculated for evaluation of Child-Pugh score grade B (Child B), pathological chronic hepatitis (CH), and liver cirrhosis (LC). We developed a novel liver functional indicator, the ABC, to count radioactivity in sequence.