Architecture of top-down signals conveyed toward extrastriate cortex revealed by rabies virus in the macaque monkey.

我们利用狂犬病毒的逆行跨突触转运，研究了沿腹侧流视觉区4 （V4）和背侧流视觉区5 （MT/V5）自上而下的多突触通路的结构。此外，我们还研究了从内侧颞叶到V4的多突触结构。我们发现MT/V5和V4的正面输入主要来自46v区域。此外，我们还发现了从海马到V4的捷径。这些结果表明，多突触结构可能提供了通过枕-颞和枕-顶叶通路完成的自上而下的目标识别信息。

We investigated the architecture of multi-synaptic top-down pathways toward visual area4 (V4) of ventral stream and visual area 5 (MT/V5) of dorsal stream, employing retrograde trans-synaptic transport of rabies virus. In addition, multi-synaptic architecture from the medial temporal lobe to V4 was also investigated. We found that frontal inputs to MT/V5 and V4 mainly arise from area 46v. In addition, we found shot-cut pathway from the hippocampus proper to V4. These results indicate that multi-synaptic architecture may provide top-down information about object recognition accomplished throughoccipito-temporal and occipito-parietal pathways.