Design and synthesis of artificial receptors for disease-related oligosaccharides, and their applications for controlling cell functions

设计并合成了在温和条件下选择性结合并有效光降解目标疾病相关寡糖的小分子。发现合成的蒽醌（AQ）-或富勒烯-硼酸杂化物选择性地结合并光降解。D-呋喃半乳糖苷，是分枝杆菌细胞壁的糖成分。此外，还发现AQ-boronic acid hybrid光降解细菌细胞壁上的目标寡糖，并诱导显著的全细胞破坏。此外，设计并合成了几种与唾液酸结合的分子。本研究结果将有助于癌症相关寡糖光降解剂的分子设计。

Small molecules, which selectively bind to and effectively photodegrade target disease-related oligosaccharides under mild conditions, were designed and synthesized. It was found that synthesized anthraquinone(AQ)-or fullerene-boronic acid hybrids selectively bound to and photodegraded.-D-galactofuranoside, which is a sugar component of mycobacterial cell wall. In addition, it was found that photodegradation of the target oligosaccharides on the bacterial cell wall by AQ-boronic acid hybrid took place and induced significant whole-cell destruction. Furthermore, several molecules that bind to sialic acid were designed and synthesized. The results obtained from this study will contribute to the molecular design of photodegrading agents for cancer-related oligosaccharides.