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Establishment of the diagnostics of Alzheimer' s disease using A・43

Establishment of the diagnostics of Alzheimer' s disease using A・43
使用A·43建立阿尔茨海默病的诊断
批准号:
23650185
负责人:
SAITO Takashi
金额:
$2.33万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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项目成果

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中文摘要
翻译
建立阿尔茨海默病(AD)的早期诊断是老龄化社会的重要任务之一。最近,我们发现AS43是以年龄依赖的方式产生的,因此它可能是一个很好的候选标记物,用于AD的早期诊断。在此,我们建立了一种高灵敏度的定量检测方法,可以在小鼠和人的样本中特异性地检测到ass43。最后,我们得出结论,AS43具有很强的致病性,可能是早期诊断AD的有用候选基因。
英文摘要
Establishment of an early diagnosis for Alzheimer’s disease (AD) is one of the important missions in an aging society. Recently, we found that Ass43 is generated under an age-dependent manner, thereby it might be a good candidate as a marker for an early diagnosis of AD. Herein, we established a high-sensitive and quantitative method to detect Ass43 specifically in the sample from mice and human materials. Finally, we concluded that Ass43 has a potent pathogenicity, and would be an useful candidate for an early diagnosis for AD.
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DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
アミロイドβ43によるアルツハイマー病の病態発症・促進機構に関する研究
β43淀粉样蛋白对阿尔茨海默病发病及促进机制的研究
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Naomasa Kakiya, Takashi Saito, Satoshi Tsubuki, Takaomi C. Saido, 斉藤貴志]
通讯作者: 斉藤貴志
Potent amyloidgenecity and pathogenicity of Aβ43
Aβ43 的有效淀粉样蛋白基因和致病性
DOI: --
发表时间: 2011
期刊: Nature Neuroscience
影响因子: 25
作者: [Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC]
通讯作者: Saido TC
APP knock-in mouse: a novel and more relevant model mouse for Alzheimer's disease
APP敲入小鼠:一种新型且更相关的阿尔茨海默病模型小鼠
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Takashi Saito, Yukio Matsuba, Naomi Mihira, Nobuhisa Iwata, Jiro Takano, Per Nilsson and Takaomi C. Saido]
通讯作者: Per Nilsson and Takaomi C. Saido
共 12 条
    Study for establishment of next-generation caries management method using dentin remineralization/regeneration technology
    • 批准号:
      18H02979
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.82万
    • 财政年份:
      2018
    • 负责人:
      SAITO Takashi
    • 依托单位:
    Development of Antisense Mediated Therapy for Exons Duplication in Duchenne Muscular Dystrophy.
    Tree- detentional Distribution of Radioactive Nuclide at Fuji Volcano and Fuji Volcanic Belt Caused by Fukushima Daiichi Nuclear Power Station Accident
    • 批准号:
      24510074
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      SAITO Takashi
    • 依托单位:
    Establishment and application of novel type of Alzheimer's disease model mouse
    海外基金