Distribution of race-specific null alleles of the FUT2 in Africa, European and Asian populations.

The expression of ABO(H)antigens in secretions such as saliva is regulated by the Secretor gene(FUT2)-encodedα(1，2)fucosyltransferase(Se Enzyme)。The ABO secretor group has at least one functional Se allele，and nonsecretors，who fail to express ABH antigens in saliva，are homozygous for the nonfunctional se allele。Our molecular analysis of the FUT2 in various population has suggested that null alleles were race-specific.The null allele se I D1428个D 1was found to be common in African(Xhosa)and Caucasians(European And Iranian)，while the null allele se I D 1357，385个D 1 was found to be common in Asian populations(Chinese，Korean，Japanese，Indonesian an Samoan)。Frequency of se I D1428 I D 1 and of se I D 1375，385 I D 1 in each population was 0.4~0.5.However，we found both se y D1428个D 1 and se I D 1375，385个D 1 in a Bangladesh population.The presence of both se y D 1428 I D 1(0.234)and se I D 1375，385 I D 1(0.074)suggests the admixture of Aryans and Asians in Bangladesh.In addition，we found se i D1 fus i D 1 as one of null alleles in Japanese(0.05-0.08)and the absence of the se I D 1 fus I D 1 in Chinese，suggesting that the se I D 1 fus i D 1 emerged from within Japanese.

The expression of ABO (H) antigens in secretions such as saliva is regulated by the Secretor gene (FUT2)-encoded α (1, 2) fucosyltransferase (Se enzyme). The ABO secretor group has at least one functional Se allele, and nonsecretors, who fail to express ABH antigens in saliva, are homozygous for the nonfunctional se allele. Our molecular analysis of the FUT2 in various population has suggested that null alleles were race-specific. The null allele seィイD1428ィエD1 was found to be common in African (Xhosa) and Caucasians (European and Iranian), while the null allele seィイD1357,385ィエD1 was found to be common in Asian populations (Chinese, Korean, Japanese, Indonesian an Samoan). Frequency of seィイD1428ィエD1 and of seィイD1375,385ィエD1 in each population was 0.4〜0.5. However, we found both seィイD1428ィエD1 and seィイD1375,385ィエD1 in a Bangladesh population. The presence of both seィイD1428ィエD1 (0.234) and seィイD1375,385ィエD1 (0.074) suggests the admixture of Aryans and Asians in Bangladesh. In addition, we found seィイD1fusィエD1 as one of null alleles in Japanese (0.05〜0.08) and the absence of the seィイD1fusィエD1 in Chinese, suggesting that the seィイD1fusィエD1 emerged from within Japanese.