Single molecule sensing on nanopillars: Reading complex molecular circuits

该项目旨在开发一种全新的纳米技术，以实时可视化动态分子电路，并在任何小至单个细胞的生物样本中显示。该项目希望在细胞生物学和传感器技术领域产生新的知识，使用创新的纳米制造和纳米流体流动来促进对细胞途径中单个蛋白质分子相互作用这一新兴领域的理解。预期成果包括一个检测单细胞中单分子的通用技术平台，有可能通过技术进步提供具有商业利益和经济效益的宝贵知识产权。

This project aims to develop an entirely new nanotechnology to visualise dynamic molecular circuits in real time, and within any biological sample as small as a single cell. This project expects to generate new knowledge in the field of cell biology and sensor technology, using innovative nanofabrication and nanoscopic fluid flows to advance understanding of the emerging field of single protein molecule interactions in cellular pathways. Expected outcomes include a universal technology platform to detect single molecules in single cells, with potential to deliver valuable intellectual property of commercial interest and economic benefit through technological advancements.