Automated Cassette-Based Radiosynthesis Equipment

项目摘要 本申请申请资助购买一台现代化的自动化PET放射化学设备 用于PET放射性示踪剂生产的盒式合成平台。该系统将安装在范德比尔特酒店 大学成像科学研究所的放射化学核心(RCC)设施；允许访问 用于三个人体PET/CT成像系统和两个临床前PET成像系统的放射性示踪剂研究 以及各种其他终端用途。核心还提供专业知识，允许研究人员开发新的 用于日常生产的放射性示踪剂。RCC目前运营GE TRACERLab MX模块作为主要GMP 一些使用率很高的放射性示踪剂的生产模块。然而，30岁的TRACERLab MX， 性能陈旧、健康状况下降的早期一代自动盒放射合成模块 超过了预计的使用期限，部件和服务都不再可用。因此，拟议的GE FastLab 2 选择用高效液相+取代现有和过时的TRACERLab MX。TRACERLAB的破损 MX将对核心支持所有正在进行的NIH资助的研究的能力造成重大中断 在这个模块上生产的放射性示踪剂。FastLab 2搭载了高效液相色谱仪，将大大提升我们的放射性示踪剂 生产能力，特别是在增加了高效液相净化系统的基础上，以盒式 放射合成模块。这种升级的能力将允许更可靠地生产一些最 要求放射性示踪剂，并允许顺利整合新开发的放射性示踪剂，以支持正在进行的 未来由NIH资助的研究。拟议的系统将放置在放射化学核心中，并用于支持 目前和未来由NIH资助的研究范围从癌症的分子基础，心血管疾病， 和神经疾病，以开发新的治疗方法。

Project Summary This application requests funding to support the purchase of a modernized automated PET radiochemistry cassette synthesis platform for PET radiotracer production. The system will be installed at the Vanderbilt University Institute of Imaging Science’s Radiochemistry Core (RCC) facility; a core that allows access to research radiotracers for use on three human PET/CT imaging systems, two pre-clinical PET imaging systems and a variety of other end uses. The core also offers expertise in allowing investigators to develop novel radiotracers for routine production. The RCC currently operates a GE TRACERLab MX module as the main GMP production module for a number of heavily utilized radiotracers. However, the TRACERLab MX, a 30-year-old, early-generation automated cassette radiosynthesis module with dated performance and declining health, has outlasted its projected use and both parts and service are no longer available. Thus, the proposed GE Fastlab 2 with HPLC+ was chosen to replace the existing and obsolete TRACERLab MX. Breakage of the TRACERLab MX would cause major disruptions to the core’s ability to support all ongoing NIH-funded studies that use radiotracers produced on this module. The Fastlab 2 with HPLC+ will substantially advance our radiotracer production capabilities, especially with the addition of the HPLC purification system married to a cassette-based radiosynthesis module. This upgraded capability would allow for more reliable production of some of the most requested radiotracers and allow for smooth integration of newly developed radiotracers to support ongoing future NIH-funded research. The proposed system will be placed in the radiochemistry core and used to support current and future NIH-funded research ranging from studying the molecular basis of cancer, cardiovascular, and neurological diseases to developing novel therapeutic approaches.