Support of Yerkes National Primate Research Center

总体-总结/摘要 本申请旨在为耶基斯人的P51基本赠款（OD 011132）寻求五年的持续支持 埃默里大学国家灵长类动物研究中心。耶基斯的首要目标是进行一次 一项研究计划，重点是与人类健康和国家卫生研究院使命有关的科学问题， 资源基础设施和适当的科学和兽医专业知识，并确保 中心作为核心科学家以及区域、国家和地区科学家的资源的能力。 化国际大在本报告所述期间（2011年5月1日至今），耶基斯中心记录了 显著的进步，如许多（>790）出版物所证明的，新动物设施的建设， 包括最先进的移植和ABSL 3设施，并逐步扩大其研究 资金基础，即使在竞争激烈的NIH资金环境的时代。此外，Yerkes 灵长类中心一直保持着杰出的核心研究计划，并提供资源和服务， 在整个地区和国家建立了广泛的多学科网络，由附属调查员和合作调查员组成。 这些研究计划，其中涉及使用各种非人类灵长类动物物种，是针对 主要针对四个主要的研究学科，代表耶基斯中心内的研究部门： 1)微生物学和免疫学; 2）发育和认知神经科学，3）神经药理学和 神经系统疾病和4）行为神经科学和精神疾病。此外，通过各司 动物资源和病理学，Yerkes提供支持，为外部调查人员进行研究， 耶基斯中心，符合我们的ORIP授权的作用，作为一个区域和国家资源。具体目标 即将到来支持期包括：1）利用非人类进行基础和转化研究， 灵长类动物扩展知识，开发改进的治疗方法，并推进造福人类的治疗方法; 2） 提供区域和国家资源，以获取数据、咨询专业知识、生物材料和专业知识。 支持非人灵长类动物研究的设施; 3）研究基础非人灵长类动物生物学， 改善非人灵长类动物的繁殖、饲养和遗传特性，以更好地为生物医学服务。 研究社区;以及4）提供涉及非人类灵长类动物的研究和培训机会， 研究生和本科生，博士后研究员，访问科学家和教职员工。的 实现这些目标将增强中心作为核心和附属机构的有利资源的能力 科学家进行非人类灵长类动物研究，都是为了促进人类健康的最终目标。

OVERALL – SUMMARY/ABSTRACT This application seeks five years of continued support for the P51 Base Grant (OD 011132) for the Yerkes National Primate Research Center of Emory University. The overarching goals of Yerkes are to conduct a research program focused on scientific problems relevant to human health and the NIH mission by providing resource infrastructure and expertise in appropriate scientific and veterinary specialties and to ensure the Center's ability to serve as a resource to Core Scientists, as well as to scientists regionally, nationally and internationally. During the current reporting period (5/1/2011 to present), the Yerkes Center has recorded remarkable progress, as evidenced by numerous (>790) publications, construction of new animal facilities, including a state-of-the-art transplantation and ABSL3 facility, and progressive expansion of its research funding base, even in the era of an extremely competitive NIH funding environment. In addition, the Yerkes Primate Center has maintained outstanding core research programs and provided resources and services to a broad multidisciplinary network of affiliate and collaborative investigators throughout the region and nation. These research programs, which involve the use of a variety of nonhuman primate species, are directed primarily toward four major research disciplines, representing the research divisions within the Yerkes Center: 1) Microbiology and Immunology; 2) Developmental and Cognitive Neuroscience, 3) Neuropharmacology and Neurologic Diseases and 4) Behavioral Neuroscience and Psychiatric Disorders. Also, through the Divisions of Animal Resources and Pathology, Yerkes provides support for outside investigators conducting research at the Yerkes Center, consistent with our ORIP-mandated role as a regional and national resource. Specific aims for the upcoming period of support include: 1) To carry out basic and translational research using nonhuman primates to expand knowledge, develop improved treatments, and advance cures that will benefit humanity; 2) To provide regional and national resources for data, consultative expertise, biologic materials, and specialized facilities useful in supporting nonhuman primate research; 3) To study basic nonhuman primate biology and improve nonhuman primate breeding, husbandry and genetic characterization to better serve the biomedical research community; and 4) To provide research and training opportunities involving nonhuman primates to graduate and undergraduate students, postdoctoral fellows, visiting scientists and faculty members. The pursuit of these aims will enhance the Center's ability to serve as an enabling resource to Core and Affiliate Scientists for the conduct of nonhuman primate research, all for the ultimate goal of advancing human health.