Translational Research in AD and related Dementias (TRADD)

摘要 亚利桑那大学（UA）培训计划，以推进阿尔茨海默病的转化研究 和AD相关痴呆旨在解决AD治疗方面的知识和经验差距 发现和临床前转化开发。为了迎接这一挑战，UA翻译研究在 AD和相关痴呆症（TRADD）培训计划旨在作为一个基于问题的翻译学习 博士前博士和医学博士的经验。博士研究员。与2012年，2015年和2018年NIH保持一致 阿尔茨海默病研究峰会和国家阿尔茨海默病项目法案，TRADD的目标 培训计划是填补学术研究生课程中存在的AD转化研究的关键空白。 为了实现这一目标，亚利桑那大学的TRADD计划将：1）在多个科学领域招募学员 学科; 2）采用基于问题的学习方法来解决AD治疗开发中的挑战 3）使培训学员具备职业发展和领导能力 在世纪进行团队科学和管理多学科团队所需的技能。通过这个 方法，我们确保TRADD学员发展AD所需的深入的翻译研究专业知识 治疗发展，同时：1）培养创造性和协作解决问题的能力 作为大规模团队科学的一部分，与翻译领域的专家合作; 2）获得 应用数据科学的理解，特别是使用AMP-AD，M2 OVE-AD和 ADNI可以加速转化研究，并为新的治疗见解提供途径; 3）连接 基因型和表型变异以及AD的多方面病因与治疗靶点的关系;以及4）获得必要的 专业和商业技能，以驾驭多样化的融资环境，并将发现转化为 临床设置。TRADD研究员将获得职业指导和领导力发展技能， 多学科团队在21世纪世纪是病人启发和数据驱动。UA TRADD培训 该计划将培养一支多元化，跨学科和专业导向的员工队伍，以满足关键的 创建一支能够推进治疗方法以预防、延迟和治疗AD和AD的工作队伍的挑战 相关的痴呆症

Abstract The University of Arizona (UA) Training Program to Advance Translational Research on Alzheimer's Disease and AD Related Dementias is designed to address knowledge and experience gaps in AD therapeutic discovery and preclinical translational development. To meet this challenge, the UA Translational Research in AD and related Dementias (TRADD) training program is designed as a problem based translational learning experience for predoctoral Ph.D and M.D. Ph.D fellows. In alignment with the 2012, 2015 and 2018 NIH Alzheimer’s Disease Research summits and the National Alzheimer’s Project Act, the goal of the TRADD training program is to fill critical gaps that exist for AD translational research in academic graduate programs. To achieve this goal, the University of Arizona TRADD program will: 1) recruit trainees across multiple scientific disciplines; 2) employ problem-based learning approaches to solve challenges in AD therapeutic development with emerging tools and techniques; and 3) equip TRADD trainees with career development and leadership skills necessary to conduct team science and manage multidisciplinary teams in the 21st century. Through this approach, we ensure that TRADD trainees develop deep translational research expertise necessary for AD therapeutic development, while: 1) cultivating the ability to creatively and collaboratively solve problems working with experts across the translational landscape as part of large-scale team science; 2) gaining an applied understanding of how data science, particularly using data generated by AMP-AD, M2OVE-AD and ADNI, can accelerate translational research and provide avenues to novel therapeutic insights; 3) connecting geno- and phenotypic variations and multifaceted etiology of AD to therapeutic targets; and 4) gaining essential professional and business skills to navigate a diverse funding landscape and translate discoveries into the clinical setting. TRADD fellows will receive career mentoring and leadership development skills to manage multi-disciplinary teams in the 21st century that is Patient Inspired and Data Driven. The UA TRADD training program will develop a diverse, cross-disciplinary and translationally oriented workforce to meet the critical challenge of creating a workforce capable of advancing therapeutics to prevent, delay and treat AD and AD related dementias.