Structures to Solve Conflicts of DNA Replication and RNA Transcription

这个项目的目的是了解新的DNA是如何在即将分裂的细胞中如此快速且没有错误地制造出来的，尽管来自应该停止或干扰它的其他过程的竞争，例如RNA的合成。该项目希望使用最新的可用方法来揭示制造DNA和RNA的微观自然机器是什么样子，以及它们是如何相互竞争获取DNA的。潜在的结果包括识别可能被小分子破坏的过程，这些小分子可能被开发成新的抗生素。这将是非常有益的--迫切需要新的抗生素作为对抗抗菌素耐药性威胁的一种方法。

This project aims to understand how new DNA is made so quickly and without mistakes in cells that are about to divide, in spite of competition from other processes happening at the same time on the DNA that should stop or interfere with it, such as the synthesis of RNA. The project expects to use the latest available methods to uncover what the microscopic natural machines that make DNA and RNA look like, and how they compete with each other for access to DNA. Potential outcomes include the identification of processes that can be compromised by small molecules that may be developed into new antibiotics. This would be of great benefit - new antibiotics are urgently needed as one approach to countering the threat of antimicrobial resistance.