Virus-inspired nanoparticles based on polyion complex micelles

病毒是自然界的纳米粒子，经过数百万年的进化，变成了智能的纳米粒子。病毒表面斑驳的独特结构激发了人们设计一种新型药物载体的灵感，这种载体利用聚合物的自组织能力。该项目旨在用智能聚合物模拟自然界的纳米颗粒，同时设计一个可以捕获治疗性蛋白质并增强其递送的平台。重点将是深入了解聚合物自组装过程，以便设计一个可应用于各种有效载荷的综合鲁棒系统。因此，具有病毒启发结构的新型纳米颗粒将被创造出来，用于输送治疗性蛋白质。

Viruses are nature's nanoparticles that have evolved over millions of years into intelligent nanoparticles. The unique structure of viruses with their patchy surface has inspired the design of a new drug carrier by employing the power of polymers to self-organize. The project aims at mimicking nature’s nanoparticles with intelligent polymers while enabling the design of a platform that can entrap therapeutic proteins and enhance their delivery. The focus will be to gain in-depth understanding on the polymer self-assembly process in order to design a synthetically robust system that can be applied to various payloads. As a result, novel nanoparticles with virus-inspired structures for the delivery of therapeutic proteins will be created.